阿托伐他汀治疗后成年男性白化病患者骨骼肌纤维结构的变化阿托伐他汀诱导肌毒性的可能机制

Journal of Cytology and Histology Pub Date : 2017-01-15 DOI:10.4172/2157-7099.1000442

Sahar Ahmed Mokhmer, E. Saber, Azza A. H. Hamouda, R. Rifaai

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引用次数: 6

摘要

方法:将大鼠随机分为4组;每组6只大鼠:第一组为对照组，给予蒸馏水;II组给予阿托伐他汀10 mg/kg/天。III组给予40 mg/kg/天的阿托伐他汀。IV组给予阿托伐他汀80 mg/kg/d。阿托伐他汀治疗8周。取出股内侧肌，快速固定，进行组织学、组织化学和免疫组织化学研究。

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Structural Changes in the Skeletal Muscle Fiber of Adult Male AlbinoRat Following Atorvastatin Treatment; the Possible Mechanisms ofAtorvastatin Induced Myotoxicity

Method: Rats were divided randomly into four groups; each group included 6 rats: Group I, the control group, received distilled water. Group II received 10 mg/kg/day of atorvastatin. Group III received 40 mg/kg/day of atorvastatin. Group IV received 80 mg/kg/day of atorvastatin. Atorvastatin was given for 8 weeks. Vastus medialis muscle was taken out, rapidly fixed and processed for histological, histochemical and immunohistochemical studies.

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Journal of Cytology and Histology

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