自闭症谱系障碍的微生物群紊乱与食物过敏我们知道什么?

P. Szachta, Anna Bartnicka, M. Gałęcka, K. Skonieczna-Żydecka
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引用次数: 2

摘要

自闭症谱系障碍(ASD)的发病机制可能是多因素的。许多研究表明自闭症儿童存在肠道生态失调。此外,胃肠道紊乱,可能是由异常的微生物群组成引起的,通常在自闭症儿童中报道。另一个可能对ASD儿童行为产生负面影响的方面是酶病(酶缺乏症)。缺乏特定的胃肠道酶会导致不适当的营养物质分解(主要是麸质和酪蛋白),并形成所谓的外啡肽,即具有阿片活性的物质(阿片疗法)。由于肠屏障和脑脊髓轴的渗透性增加,外啡肽和其他不适当消化的食物颗粒可能被运送到中枢神经系统。因此,可以观察到大脑发育障碍和儿童行为恶化。研究表明,肠道菌群紊乱和肠道通透性增加都可能导致行为障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbiota disorders and food hypersensitivity in autism spectrum disorders; what do we know?
Pathogenesis of autism spectrum disorders (ASD) is probably multifactorial. Many studies have shown intestinal dysbiosis in children with autism. Moreover, gastrointestinal disturbances, probably resulting from abnormal microbiota composition, are commonly reported in children with autism. Another aspect, that may have negative influence on ASD children’s behavior are enzymopathies (enzymatic deficiency). Lack of selected gastrointestinal enzymes leads to inappropriate nutrients decomposition (mainly gluten and casein) and formation of so called exorphins, i.e. substances with opioid activity (opioid therapy). Because of increased permeability of the intestinal barrier and cerebrospinal axis, exorphins and others improperly digested food particles may be transported to the central nervous system. Consequently, disorders in brain development and children’s behavior deterioration may be observed. Studies have shown that both microflora disorders and increased intestinal permeability may contribute to behavioral impairment.
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