{"title":"肾切除术后血浆血管紧张素原增高的原因。单侧或双侧肾切除或手术后正常大鼠、肾高血压大鼠和DOCA +盐处理大鼠肾素系统的变化。","authors":"J. Bing, K. Poulsen","doi":"10.1111/J.1699-0463.1970.TB03519.X","DOIUrl":null,"url":null,"abstract":"24 hours after nephrectomy there is an increase in plasma angiotensinogen which is 2 to 3 times increased in unilaterally nephrectomized rats and 5 to 12 times increased in bilaterally nephrectomized rats. In normal rats, DOCA + salt treated rats and renal hypertensive rats, the postnephrectomy changes are about the same, independent of the marked differences in their pre-operative plasma and renal renin. The postnephrectomy increase in angiotensinogen must therefore be due to loss of some internal factor other than renin or to loss of some external renal function. Both shamoperation and unilateral nephrectomy are followed by a marked decrease in plasma renin, the postoperative fall being more pronounced after removal of a clamped kidney than after removal of a normal.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"85 1","pages":"669-73"},"PeriodicalIF":0.0000,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Cause of increased plasma angiotensinogen after nephrectomy. The renin-system in normal, renal hypertensive and DOCA + salt treated rats after unilateral or bilateral nephrectomy or shamoperation.\",\"authors\":\"J. Bing, K. Poulsen\",\"doi\":\"10.1111/J.1699-0463.1970.TB03519.X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"24 hours after nephrectomy there is an increase in plasma angiotensinogen which is 2 to 3 times increased in unilaterally nephrectomized rats and 5 to 12 times increased in bilaterally nephrectomized rats. In normal rats, DOCA + salt treated rats and renal hypertensive rats, the postnephrectomy changes are about the same, independent of the marked differences in their pre-operative plasma and renal renin. The postnephrectomy increase in angiotensinogen must therefore be due to loss of some internal factor other than renin or to loss of some external renal function. Both shamoperation and unilateral nephrectomy are followed by a marked decrease in plasma renin, the postoperative fall being more pronounced after removal of a clamped kidney than after removal of a normal.\",\"PeriodicalId\":6953,\"journal\":{\"name\":\"Acta pathologica et microbiologica Scandinavica. Section A, Pathology\",\"volume\":\"85 1\",\"pages\":\"669-73\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta pathologica et microbiologica Scandinavica. Section A, Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/J.1699-0463.1970.TB03519.X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.1699-0463.1970.TB03519.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cause of increased plasma angiotensinogen after nephrectomy. The renin-system in normal, renal hypertensive and DOCA + salt treated rats after unilateral or bilateral nephrectomy or shamoperation.
24 hours after nephrectomy there is an increase in plasma angiotensinogen which is 2 to 3 times increased in unilaterally nephrectomized rats and 5 to 12 times increased in bilaterally nephrectomized rats. In normal rats, DOCA + salt treated rats and renal hypertensive rats, the postnephrectomy changes are about the same, independent of the marked differences in their pre-operative plasma and renal renin. The postnephrectomy increase in angiotensinogen must therefore be due to loss of some internal factor other than renin or to loss of some external renal function. Both shamoperation and unilateral nephrectomy are followed by a marked decrease in plasma renin, the postoperative fall being more pronounced after removal of a clamped kidney than after removal of a normal.