Filizi Bilir, Didem Batman, Aydın Çorakçi, İzzet Yücesoy
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摘要

背景:宫颈癌是最常见的妇科恶性肿瘤,也是全世界妇女癌症相关死亡的主要原因。癌症患者的全身炎症反应影响营养、功能和预后。在一些恶性肿瘤中,不良的营养健康与较差的预后有关。一种新的评分方法叫做血红蛋白-白蛋白-淋巴细胞-血小板(HALP)指数,是利用饮食和炎症缺乏症开发出来的。方法:回顾性分析2012年1月至2020年12月宫颈癌手术诊断的CC患者。预处理血红蛋白(Hb)、白蛋白(Alb)、淋巴细胞计数(Lc)和血小板(Plt)测量用于实验室研究。结果:本回顾性研究发现74例非转移性宫颈癌(中位年龄55岁,年龄从30岁到86岁不等)。根据FIGO分期,1期和2期患者比例分别为78%(58例)和22%(16例)。将中性粒细胞淋巴细胞比率(NLR)、血小板淋巴细胞比率(PLR)、HALP指数与LVSI、参数侵袭、肿瘤大小、组织学类型、住院时间等指标进行比较;我们在分析中找不到任何显著的相关性。结论:NLR、PLR、HALP指数对早期可手术宫颈癌患者的病理特征无预后价值。前瞻性多中心和更多患者研究将阐明血液学参数如何影响肿瘤预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ameliyat edilebilir Rahim Ağzı Kanserinde Hematolojik İnflamatuar Belirteçler ile Genel Özellikler Arasındaki İlişki; HALP indeksinin yeri.
Background: Cervical cancer is the most common gynecologic malignancy and the leading cause of cancer-related mortality in women worldwide. Systemic inflammatory reactions in cancer patients impact nutrition, function, and prognosis. Poor nutritional health is linked to a worse prognosis in several malignancies. A new score called the hemoglobin-albumin-lymphocyte-platelet (HALP) index was developed using dietary and inflammatory deficiencies. Method: This retrospective study and CC patients diagnosed from January 2012 to December 2020 who were operated for cervical cancer. Pre-treatment hemoglobin (Hb), albumin (Alb), lymphocyte count (Lc), and platelet (Plt) measurements were made for laboratory research. Results: This retrospective study revealed 74 non-metastatic cervical cancer (median age was 55, ranging from 30 to 86 years). According to the FIGO stage, the percentage of stages 1 and 2 were 78% (58 patients), and 22% (16 patients). Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), and HALP index were analyzed with LVSI, parametrial invasion, tumor size, histologic type, and duration of hospital stay; we could not find any significant correlation between the analysis. Conclusion: NLR, PLR, and HALP index have no prognostic value in early operable cervical cancer patients regarding the pathologic features. Prospective multicenter and more patient studies will clarify how the hematologic parameters affect oncologic outcomes.
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