M. Inomata, K. Azechi, N. Takata, K. Hayashi, K. Tokui, C. Taka, S. Okazawa, K. Kambara, S. Imanishi, T. Miwa, Ryuji Hayashi, Shoko Matsui, K. Tobe
{"title":"免疫检查点抑制剂对老年非小细胞肺癌患者生存的影响","authors":"M. Inomata, K. Azechi, N. Takata, K. Hayashi, K. Tokui, C. Taka, S. Okazawa, K. Kambara, S. Imanishi, T. Miwa, Ryuji Hayashi, Shoko Matsui, K. Tobe","doi":"10.31487/j.cor.2020.12.04","DOIUrl":null,"url":null,"abstract":"Purpose: We analysed the relationship between a history of immune checkpoint inhibitor (ICI) and overall\nsurvival in elderly patients with non-small cell lung cancer (NSCLC).\nMethods: We conducted a retrospective analysis of the data of patients with NSCLC aged ≥70-year-old\nwho had received systemic anticancer therapy between 2015 and 2019.\nResults: The analysis included the data of a total of 63 patients. Multivariate analysis revealed a significant\nassociation between a history of treatment with ICI and the overall survival. A significant interaction was\nalso observed between a history of treatment with an ICI and the tumor histology.\nConclusion: A significant association between history of ICI therapy and the overall survival was detected\nin elderly NSCLC patients aged ≥70-year-old in a clinical practice setting. Our results also suggested that\nthe impact of ICI therapy on the survival differed depending on the tumor histology.\n","PeriodicalId":10487,"journal":{"name":"Clinical Oncology and Research","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Immune Checkpoint Inhibitor on the Survival in Elderly Patients with Non-Small Cell Lung Cancer\",\"authors\":\"M. Inomata, K. Azechi, N. Takata, K. Hayashi, K. Tokui, C. Taka, S. Okazawa, K. Kambara, S. Imanishi, T. Miwa, Ryuji Hayashi, Shoko Matsui, K. Tobe\",\"doi\":\"10.31487/j.cor.2020.12.04\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: We analysed the relationship between a history of immune checkpoint inhibitor (ICI) and overall\\nsurvival in elderly patients with non-small cell lung cancer (NSCLC).\\nMethods: We conducted a retrospective analysis of the data of patients with NSCLC aged ≥70-year-old\\nwho had received systemic anticancer therapy between 2015 and 2019.\\nResults: The analysis included the data of a total of 63 patients. Multivariate analysis revealed a significant\\nassociation between a history of treatment with ICI and the overall survival. A significant interaction was\\nalso observed between a history of treatment with an ICI and the tumor histology.\\nConclusion: A significant association between history of ICI therapy and the overall survival was detected\\nin elderly NSCLC patients aged ≥70-year-old in a clinical practice setting. Our results also suggested that\\nthe impact of ICI therapy on the survival differed depending on the tumor histology.\\n\",\"PeriodicalId\":10487,\"journal\":{\"name\":\"Clinical Oncology and Research\",\"volume\":\"66 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oncology and Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31487/j.cor.2020.12.04\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oncology and Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31487/j.cor.2020.12.04","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of Immune Checkpoint Inhibitor on the Survival in Elderly Patients with Non-Small Cell Lung Cancer
Purpose: We analysed the relationship between a history of immune checkpoint inhibitor (ICI) and overall
survival in elderly patients with non-small cell lung cancer (NSCLC).
Methods: We conducted a retrospective analysis of the data of patients with NSCLC aged ≥70-year-old
who had received systemic anticancer therapy between 2015 and 2019.
Results: The analysis included the data of a total of 63 patients. Multivariate analysis revealed a significant
association between a history of treatment with ICI and the overall survival. A significant interaction was
also observed between a history of treatment with an ICI and the tumor histology.
Conclusion: A significant association between history of ICI therapy and the overall survival was detected
in elderly NSCLC patients aged ≥70-year-old in a clinical practice setting. Our results also suggested that
the impact of ICI therapy on the survival differed depending on the tumor histology.
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