{"title":"天然毒素与同一个健康:综述","authors":"Azubuike Raphael Nwaji , Onikisateinba Arieri , Annabel Sharon Anyang , Kaze Nguedia , Etomi Barbara Abiade , Gilead Ebiegberi Forcados , Olusola Olalekan Oladipo , Sunday Makama , Ishaku Leo Elisha , Nonyelim Ozele , Jurbe Gofwan Gotep","doi":"10.1016/j.soh.2023.100013","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The One Health concept considers the interconnectivity, interactions and interdependence of humans, animals and the environment. Humans, animals and other organisms are constantly exposed to a wide range of natural toxins present in the environment. Thus, there is growing concern about the potential detrimental effects that natural toxins could pose to achieve One Health. Interestingly, alkaloids, steroids and bioactive peptides obtained from natural toxins could be used for the development of therapeutic agents.</p></div><div><h3>Methodology</h3><p>Our literature search focused on the following keywords; toxins, One Health, microbial toxins, mycotoxins, phytotoxins, phycotoxins, insect toxins and toxin effects. Google Scholar, Science Direct, PubMed and Web of Science were the search engines used to obtain primary databases. We chose relevant full-text articles and review papers published in English language only. The research was done between July 2022 and January 2023.</p></div><div><h3>Results</h3><p>Natural toxins are poisonous substances comprising bioactive compounds produced by microorganisms, invertebrates, plants and animals. These compounds possess diverse structures and differ in biological function and toxicity, posing risks to human and animal health through the contamination of the environment, causing disease or death in certain cases. Findings from the articles reviewed revealed that effects of natural toxins on animals and humans gained more attention than the impact of natural toxins on the environment and lower organisms, irrespective of the significant roles that lower organisms play to maintain ecosystem balance. Also, systematic approaches for toxin control in the environment and utilization for beneficial purposes are inadequate in many regions. Remarkably, bioactive compounds present in natural toxins have potential for the development of therapeutic agents. These findings suggest that global, comprehensive and coordinated efforts are required for improved management of natural toxins through an interdisciplinary, One Health approach.</p></div><div><h3>Conclusion</h3><p>Adopting a One Health approach is critical to addressing the effects of natural toxins on the health of humans, animals and the environment.</p></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949704323000070/pdfft?md5=d995738114bccf425ad9034d75c786d6&pid=1-s2.0-S2949704323000070-main.pdf","citationCount":"2","resultStr":"{\"title\":\"Natural toxins and One Health: a review\",\"authors\":\"Azubuike Raphael Nwaji , Onikisateinba Arieri , Annabel Sharon Anyang , Kaze Nguedia , Etomi Barbara Abiade , Gilead Ebiegberi Forcados , Olusola Olalekan Oladipo , Sunday Makama , Ishaku Leo Elisha , Nonyelim Ozele , Jurbe Gofwan Gotep\",\"doi\":\"10.1016/j.soh.2023.100013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The One Health concept considers the interconnectivity, interactions and interdependence of humans, animals and the environment. Humans, animals and other organisms are constantly exposed to a wide range of natural toxins present in the environment. Thus, there is growing concern about the potential detrimental effects that natural toxins could pose to achieve One Health. Interestingly, alkaloids, steroids and bioactive peptides obtained from natural toxins could be used for the development of therapeutic agents.</p></div><div><h3>Methodology</h3><p>Our literature search focused on the following keywords; toxins, One Health, microbial toxins, mycotoxins, phytotoxins, phycotoxins, insect toxins and toxin effects. Google Scholar, Science Direct, PubMed and Web of Science were the search engines used to obtain primary databases. We chose relevant full-text articles and review papers published in English language only. The research was done between July 2022 and January 2023.</p></div><div><h3>Results</h3><p>Natural toxins are poisonous substances comprising bioactive compounds produced by microorganisms, invertebrates, plants and animals. These compounds possess diverse structures and differ in biological function and toxicity, posing risks to human and animal health through the contamination of the environment, causing disease or death in certain cases. Findings from the articles reviewed revealed that effects of natural toxins on animals and humans gained more attention than the impact of natural toxins on the environment and lower organisms, irrespective of the significant roles that lower organisms play to maintain ecosystem balance. Also, systematic approaches for toxin control in the environment and utilization for beneficial purposes are inadequate in many regions. Remarkably, bioactive compounds present in natural toxins have potential for the development of therapeutic agents. These findings suggest that global, comprehensive and coordinated efforts are required for improved management of natural toxins through an interdisciplinary, One Health approach.</p></div><div><h3>Conclusion</h3><p>Adopting a One Health approach is critical to addressing the effects of natural toxins on the health of humans, animals and the environment.</p></div>\",\"PeriodicalId\":101146,\"journal\":{\"name\":\"Science in One Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2949704323000070/pdfft?md5=d995738114bccf425ad9034d75c786d6&pid=1-s2.0-S2949704323000070-main.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science in One Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949704323000070\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science in One Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949704323000070","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
“同一个健康”概念考虑了人类、动物和环境之间的相互联系、相互作用和相互依存。人类、动物和其他生物不断暴露于环境中存在的各种天然毒素。因此，人们越来越关注天然毒素可能对实现“同一个健康”造成的潜在有害影响。有趣的是，从天然毒素中提取的生物碱、类固醇和生物活性肽可用于开发治疗剂。你的文献检索集中在以下关键词上;毒素，One Health，微生物毒素，真菌毒素，植物毒素，藻毒素，昆虫毒素和毒素效应。Google Scholar、Science Direct、PubMed和Web of Science是用来获取主数据库的搜索引擎。我们选择了只以英文发表的相关全文文章和综述论文。这项研究是在2022年7月至2023年1月之间进行的。结果天然毒素是由微生物、无脊椎动物、植物和动物产生的含有生物活性化合物的有毒物质。这些化合物具有不同的结构和不同的生物功能和毒性，通过污染环境对人类和动物健康构成风险，在某些情况下导致疾病或死亡。综述文章的发现表明，天然毒素对动物和人类的影响比天然毒素对环境和低等生物的影响更受关注，而不考虑低等生物在维持生态系统平衡方面发挥的重要作用。此外，在许多地区，在环境中控制毒素和为有益目的利用毒素的系统方法是不够的。值得注意的是，天然毒素中存在的生物活性化合物具有开发治疗剂的潜力。这些发现表明，需要通过跨学科的“同一个健康”方法，在全球范围内作出全面和协调的努力，以改进对天然毒素的管理。结论采取“同一个健康”方针对于解决天然毒素对人类、动物和环境健康的影响至关重要。
The One Health concept considers the interconnectivity, interactions and interdependence of humans, animals and the environment. Humans, animals and other organisms are constantly exposed to a wide range of natural toxins present in the environment. Thus, there is growing concern about the potential detrimental effects that natural toxins could pose to achieve One Health. Interestingly, alkaloids, steroids and bioactive peptides obtained from natural toxins could be used for the development of therapeutic agents.
Methodology
Our literature search focused on the following keywords; toxins, One Health, microbial toxins, mycotoxins, phytotoxins, phycotoxins, insect toxins and toxin effects. Google Scholar, Science Direct, PubMed and Web of Science were the search engines used to obtain primary databases. We chose relevant full-text articles and review papers published in English language only. The research was done between July 2022 and January 2023.
Results
Natural toxins are poisonous substances comprising bioactive compounds produced by microorganisms, invertebrates, plants and animals. These compounds possess diverse structures and differ in biological function and toxicity, posing risks to human and animal health through the contamination of the environment, causing disease or death in certain cases. Findings from the articles reviewed revealed that effects of natural toxins on animals and humans gained more attention than the impact of natural toxins on the environment and lower organisms, irrespective of the significant roles that lower organisms play to maintain ecosystem balance. Also, systematic approaches for toxin control in the environment and utilization for beneficial purposes are inadequate in many regions. Remarkably, bioactive compounds present in natural toxins have potential for the development of therapeutic agents. These findings suggest that global, comprehensive and coordinated efforts are required for improved management of natural toxins through an interdisciplinary, One Health approach.
Conclusion
Adopting a One Health approach is critical to addressing the effects of natural toxins on the health of humans, animals and the environment.
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