{"title":"医护人员预防性使用羟氯喹和随后的SARS-CoV-2感染——一项匹配病例-对照研究","authors":"R. Kaur","doi":"10.24321/2455.7048.202201","DOIUrl":null,"url":null,"abstract":"Introduction: Healthcare Workers (HCWs) are at a higher risk of contracting SARS-CoV-2 infection as they have greater exposure to confirmed COVID-19 patients. It is essential to implement prophylactic measures to reduce the incidence of COVID-19 among them. The Indian guidelines recommend the use of hydroxychloroquine (HCQ) as prophylaxis for HCWs. Objective: To investigate the role of HCQ as prophylaxis against SARS-CoV-2 infection among HCWs.Method: The cases and controls were matched at an individual level on occupation (doctor, nurse, technical staff, attending/ cleaning staff, administrative staff), area of posting (whether designated COVID care area or non-COVID area), use of personal protective equipment (PPE), and risk category of exposure.Results: In matched-pair analysis, no statistically significant difference was found in the incidence of COVID-19 infection with the use of HCQ for prophylaxis (OR 0.73, 95% CI: 0.40-1.36).Conclusion: Prophylactic use of HCQ does not have any effect on the prevention of COVID-19 infection.","PeriodicalId":89674,"journal":{"name":"Epidemiology Research International","volume":"467 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prophylactic Use of Hydroxychloroquine and Subsequent SARS-CoV-2 Infection among Healthcare Workers - A Matched Case-control Study\",\"authors\":\"R. Kaur\",\"doi\":\"10.24321/2455.7048.202201\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Healthcare Workers (HCWs) are at a higher risk of contracting SARS-CoV-2 infection as they have greater exposure to confirmed COVID-19 patients. It is essential to implement prophylactic measures to reduce the incidence of COVID-19 among them. The Indian guidelines recommend the use of hydroxychloroquine (HCQ) as prophylaxis for HCWs. Objective: To investigate the role of HCQ as prophylaxis against SARS-CoV-2 infection among HCWs.Method: The cases and controls were matched at an individual level on occupation (doctor, nurse, technical staff, attending/ cleaning staff, administrative staff), area of posting (whether designated COVID care area or non-COVID area), use of personal protective equipment (PPE), and risk category of exposure.Results: In matched-pair analysis, no statistically significant difference was found in the incidence of COVID-19 infection with the use of HCQ for prophylaxis (OR 0.73, 95% CI: 0.40-1.36).Conclusion: Prophylactic use of HCQ does not have any effect on the prevention of COVID-19 infection.\",\"PeriodicalId\":89674,\"journal\":{\"name\":\"Epidemiology Research International\",\"volume\":\"467 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemiology Research International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24321/2455.7048.202201\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiology Research International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24321/2455.7048.202201","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prophylactic Use of Hydroxychloroquine and Subsequent SARS-CoV-2 Infection among Healthcare Workers - A Matched Case-control Study
Introduction: Healthcare Workers (HCWs) are at a higher risk of contracting SARS-CoV-2 infection as they have greater exposure to confirmed COVID-19 patients. It is essential to implement prophylactic measures to reduce the incidence of COVID-19 among them. The Indian guidelines recommend the use of hydroxychloroquine (HCQ) as prophylaxis for HCWs. Objective: To investigate the role of HCQ as prophylaxis against SARS-CoV-2 infection among HCWs.Method: The cases and controls were matched at an individual level on occupation (doctor, nurse, technical staff, attending/ cleaning staff, administrative staff), area of posting (whether designated COVID care area or non-COVID area), use of personal protective equipment (PPE), and risk category of exposure.Results: In matched-pair analysis, no statistically significant difference was found in the incidence of COVID-19 infection with the use of HCQ for prophylaxis (OR 0.73, 95% CI: 0.40-1.36).Conclusion: Prophylactic use of HCQ does not have any effect on the prevention of COVID-19 infection.