BRAF抑制剂与抗氧化剂对光毒性的比较分析

Photodermatology Pub Date : 2020-03-01 DOI:10.1111/phpp.12520

M. Heppt, B. Clanner-Engelshofen, Enklajd Marsela, A. Wessely, C. Kammerbauer, B. Przybilla, L. French, C. Berking, M. Reinholz

{"title":"BRAF抑制剂与抗氧化剂对光毒性的比较分析","authors":"M. Heppt, B. Clanner-Engelshofen, Enklajd Marsela, A. Wessely, C. Kammerbauer, B. Przybilla, L. French, C. Berking, M. Reinholz","doi":"10.1111/phpp.12520","DOIUrl":null,"url":null,"abstract":"Small molecules tackling mutated BRAF (BRAFi) are an important mainstay of targeted therapy in a variety of cancers including melanoma. Albeit commonly reported as side effect, the phototoxic potential of many BRAFi is poorly characterized. In this study, we evaluated the phototoxicity of 17 distinct agents and investigated whether BRAFi‐induced phototoxicity can be alleviated by antioxidants.","PeriodicalId":20060,"journal":{"name":"Photodermatology","volume":"332 1","pages":"126 - 134"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Comparative analysis of the phototoxicity induced by BRAF inhibitors and alleviation through antioxidants\",\"authors\":\"M. Heppt, B. Clanner-Engelshofen, Enklajd Marsela, A. Wessely, C. Kammerbauer, B. Przybilla, L. French, C. Berking, M. Reinholz\",\"doi\":\"10.1111/phpp.12520\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Small molecules tackling mutated BRAF (BRAFi) are an important mainstay of targeted therapy in a variety of cancers including melanoma. Albeit commonly reported as side effect, the phototoxic potential of many BRAFi is poorly characterized. In this study, we evaluated the phototoxicity of 17 distinct agents and investigated whether BRAFi‐induced phototoxicity can be alleviated by antioxidants.\",\"PeriodicalId\":20060,\"journal\":{\"name\":\"Photodermatology\",\"volume\":\"332 1\",\"pages\":\"126 - 134\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/phpp.12520\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/phpp.12520","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 7

摘要

小分子治疗突变BRAF (BRAFi)是包括黑色素瘤在内的多种癌症靶向治疗的重要支柱。尽管通常报道为副作用，但许多BRAFi的光毒性潜能尚未明确。在这项研究中，我们评估了17种不同药物的光毒性，并研究了抗氧化剂是否可以减轻BRAFi诱导的光毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Comparative analysis of the phototoxicity induced by BRAF inhibitors and alleviation through antioxidants

Small molecules tackling mutated BRAF (BRAFi) are an important mainstay of targeted therapy in a variety of cancers including melanoma. Albeit commonly reported as side effect, the phototoxic potential of many BRAFi is poorly characterized. In this study, we evaluated the phototoxicity of 17 distinct agents and investigated whether BRAFi‐induced phototoxicity can be alleviated by antioxidants.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Photodermatology

自引率

0.00%

发文量