{"title":"迷迭香提取物的抗氧化和抗胆碱酯酶作用:一项双盲随机对照试验","authors":"Fatemeh Dabaghzadeh , Mitra Mehrabani , Homa Abdollahi , Somayyeh Karami-Mohajeri","doi":"10.1016/j.aimed.2021.03.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The present study was aimed at investigating the effect of <span><em>Salvia</em><span><em> </em><em>rosmarinus</em></span></span> (syn: <em>Rosmarinus officinalis</em><span><span> L.; rosemary) extract on acetyl cholinesterase (AChE) activity and </span>oxidative stress biomarkers in healthy volunteers.</span></p></div><div><h3>Method</h3><p><span>In a double-blind randomized controlled trial<span><span>, 50 healthy participants (21–25 years old) were divided into two groups: placebo (N = 25) and rosemary (N = 25). The rosemary and placebo groups respectively received rosemary (500 mg rosemary powder) and placebo capsules (500 mg starch powder) twice a day for one month. AChE activity, total </span>antioxidant capacity<span> (TAC), lipid peroxidation, and </span></span></span>protein carbonylation were determined in blood samples before and after the trial.</p></div><div><h3>Discussion</h3><p><span>Administration of 1000 mg of rosemary for 30 days significantly decreased AChE activity compared to AChE activity before rosemary treatment (</span><em>p</em> value<0.001) and also in the placebo group (p value<0.01). Notably, administration of rosemary considerably improved TAC (<em>p</em> value<0.01) and protein carbonylation (<em>p</em> value<0.05) compared to those values before rosemary treatment and in the placebo group. After administration of rosemary, no significant changes were observed in lipid peroxidation (p value>0.05) compared to that value before rosemary treatment and in the placebo group.</p></div><div><h3>Conclusion</h3><p>The findings indicated the inhibitory effect of rosemary on AChE activity and the improvement of non-enzymatic antioxidant defense system. The results may reinforce the use of rosemary as a potential antioxidant supplement. Further evaluations are recommended to find out the effectiveness of rosemary in patients with Alzheimer’s disease.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"9 1","pages":"Pages 69-74"},"PeriodicalIF":1.7000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.aimed.2021.03.002","citationCount":"2","resultStr":"{\"title\":\"Antioxidant and anticholinesterase effects of rosemary (Salvia rosmarinus) extract: A double-blind randomized controlled trial\",\"authors\":\"Fatemeh Dabaghzadeh , Mitra Mehrabani , Homa Abdollahi , Somayyeh Karami-Mohajeri\",\"doi\":\"10.1016/j.aimed.2021.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The present study was aimed at investigating the effect of <span><em>Salvia</em><span><em> </em><em>rosmarinus</em></span></span> (syn: <em>Rosmarinus officinalis</em><span><span> L.; rosemary) extract on acetyl cholinesterase (AChE) activity and </span>oxidative stress biomarkers in healthy volunteers.</span></p></div><div><h3>Method</h3><p><span>In a double-blind randomized controlled trial<span><span>, 50 healthy participants (21–25 years old) were divided into two groups: placebo (N = 25) and rosemary (N = 25). The rosemary and placebo groups respectively received rosemary (500 mg rosemary powder) and placebo capsules (500 mg starch powder) twice a day for one month. AChE activity, total </span>antioxidant capacity<span> (TAC), lipid peroxidation, and </span></span></span>protein carbonylation were determined in blood samples before and after the trial.</p></div><div><h3>Discussion</h3><p><span>Administration of 1000 mg of rosemary for 30 days significantly decreased AChE activity compared to AChE activity before rosemary treatment (</span><em>p</em> value<0.001) and also in the placebo group (p value<0.01). Notably, administration of rosemary considerably improved TAC (<em>p</em> value<0.01) and protein carbonylation (<em>p</em> value<0.05) compared to those values before rosemary treatment and in the placebo group. After administration of rosemary, no significant changes were observed in lipid peroxidation (p value>0.05) compared to that value before rosemary treatment and in the placebo group.</p></div><div><h3>Conclusion</h3><p>The findings indicated the inhibitory effect of rosemary on AChE activity and the improvement of non-enzymatic antioxidant defense system. The results may reinforce the use of rosemary as a potential antioxidant supplement. Further evaluations are recommended to find out the effectiveness of rosemary in patients with Alzheimer’s disease.</p></div>\",\"PeriodicalId\":7343,\"journal\":{\"name\":\"Advances in integrative medicine\",\"volume\":\"9 1\",\"pages\":\"Pages 69-74\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.aimed.2021.03.002\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in integrative medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212958821000215\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in integrative medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212958821000215","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Antioxidant and anticholinesterase effects of rosemary (Salvia rosmarinus) extract: A double-blind randomized controlled trial
Objective
The present study was aimed at investigating the effect of Salviarosmarinus (syn: Rosmarinus officinalis L.; rosemary) extract on acetyl cholinesterase (AChE) activity and oxidative stress biomarkers in healthy volunteers.
Method
In a double-blind randomized controlled trial, 50 healthy participants (21–25 years old) were divided into two groups: placebo (N = 25) and rosemary (N = 25). The rosemary and placebo groups respectively received rosemary (500 mg rosemary powder) and placebo capsules (500 mg starch powder) twice a day for one month. AChE activity, total antioxidant capacity (TAC), lipid peroxidation, and protein carbonylation were determined in blood samples before and after the trial.
Discussion
Administration of 1000 mg of rosemary for 30 days significantly decreased AChE activity compared to AChE activity before rosemary treatment (p value<0.001) and also in the placebo group (p value<0.01). Notably, administration of rosemary considerably improved TAC (p value<0.01) and protein carbonylation (p value<0.05) compared to those values before rosemary treatment and in the placebo group. After administration of rosemary, no significant changes were observed in lipid peroxidation (p value>0.05) compared to that value before rosemary treatment and in the placebo group.
Conclusion
The findings indicated the inhibitory effect of rosemary on AChE activity and the improvement of non-enzymatic antioxidant defense system. The results may reinforce the use of rosemary as a potential antioxidant supplement. Further evaluations are recommended to find out the effectiveness of rosemary in patients with Alzheimer’s disease.
期刊介绍：
Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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