聚致发射四苯乙烯功能化n-杂环碳稳定金纳米粒子的合成与表征

IF 1.1 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Marilyne Bélanger-Bouliga, N. Kihal, Hanae Mahious, P. T. Nguyen, S. Bourgault, A. Nazemi
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引用次数: 0

摘要

金纳米颗粒(AuNPs)在催化和纳米医学等领域有着广泛的应用。尽管硫醇基aunp已经被广泛研究,但它们在各种条件下(如高温和低温、pH变化)都相对不稳定,并且容易氧化。在过去的十年中,n -杂环碳烯(NHCs)作为稳定金属纳米颗粒和表面的合适配体受到了人们的关注。虽然nhc功能化的aunp在稳定性方面已被证明优于基于巯基的类似物,但它们在纳米医学中的应用尚未实现。杂化纳米材料,如以具有聚集诱导发射(AIE)特性的π共轭分子标记的AuNPs,是开发细胞成像荧光材料的有希望的候选材料。将nhc稳定的AuNPs与AIE结合形成稳定的荧光杂化AuNPs具有重要意义,为开发新的nhc基纳米材料打开了大门。在此,我们报道了水溶性荧光nhc修饰的AuNPs的合成和表征,这些AuNPs在纳米医学中具有潜在的应用前景。研究了它们在生物学相关条件下的稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and characterization of tetraphenylethylene-functionalized N-heterocyclic carbene-stabilized gold nanoparticles with aggregation-induced emission
Gold nanoparticles (AuNPs) have found use in broad range of applications such as in catalysis and nanomedicine. Despite the fact that thiol-based AuNPs have been widely studied, they suffer from relative instability in various conditions, such as high and low temperatures, pH variations, and are prone to oxidation. Over the last decade, N-heterocyclic carbenes (NHCs) have been under spotlight as suitable ligands to stabilize metal nanoparticles and surfaces. Although NHC-functionalized AuNPs have been shown to outperform their thiol-based analogs in terms of stability, their applications in nanomedicine have not been realized. Hybrid nanomaterials, such as AuNPs tagged with π-conjugated molecules with aggregation-induced emission (AIE) property, are promising candidates to develop fluorescent materials for cellular imaging. The combination of NHC-stabilized AuNPs with AIE to form stable, fluorescent hybrid AuNPs is of significant interest to open the door to develop new NHC-based nanomaterials. Herein, we report the synthesis and characterization of water-soluble fluorescent NHC-decorated AuNPs for potential applications in nanomedicine. Their stability in biologically relevant conditions is investigated.
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来源期刊
Canadian Journal of Chemistry
Canadian Journal of Chemistry 化学-化学综合
CiteScore
1.90
自引率
9.10%
发文量
99
审稿时长
1 months
期刊介绍: Published since 1929, the Canadian Journal of Chemistry reports current research findings in all branches of chemistry. It includes the traditional areas of analytical, inorganic, organic, and physical-theoretical chemistry and newer interdisciplinary areas such as materials science, spectroscopy, chemical physics, and biological, medicinal and environmental chemistry. Articles describing original research are welcomed.
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