既往感染过程后一过性蛋白S缺乏、并发症及结局:临床一例

O. Gordeeva, Albina V. Dobrotok, L. Selimzianova, Valeria A. Deeva
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引用次数: 0

摘要

背景。暴发性紫癜(PF) -是一种急性进行性血栓形成的小直径血管主要位于四肢皮肤。PF的特点是死亡率高。病人可能会有严重的后果,包括截肢和失去手指、脚甚至四肢。临床病例描述。本文报道一例3岁男童因既往感染急性中耳炎后第7天出现短暂性S蛋白缺乏并发特发性PF的临床病例。疾病在几个小时内就恶化了。患者四肢皮肤出现出血性元素,后来出现组织坏死。所进行的治疗有助于阻止PF形式的病理过程,也防止了儿童严重致残并发症的发展。鉴别诊断和治疗应该是快速和准确的,因为PF的发展发生在短短几小时内。诊断应包括扩大的凝血试验和仪器检查,这决定了在止血系统疾病患者管理中采用多学科方法的合理性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transient deficiency of protein S after past infection process, complications and outcome: clinical case
Background. Purpura fulminans (PF) – is an acute rapidly progressive thrombosis of small-diameter blood vessels located mainly on the skin of the extremities. PF is characterized by high mortality rates. Patients can have serious consequences, including amputations and loss of fingers, foots or even extremities in general.Clinical case description. A clinical case of developing transient deficiency of protein S complicated by idiopathic PF on the 7th day after acute otitis in a 3-year-old boy due to past infection is presented. The progression of the disease developed within a few hours. The patient became hemorrhagic elements on the skin of extremities, and later — tissue necrosis. The conducted therapy facilitated to stop the pathological process in the form of PF, and also prevented the development of severe disabling complications in the child.Conclusion. Differential diagnosis and treatment should be fast and accurate, as the development of PF occurs in mere hours. Diagnostics should include expanded panel of coagulological tests and instrumental examinations, which determines the justifiability of a multidisciplinary approach in the patient management with disorders in the hemostatic system. 
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