Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation

Objective: To compare mean change in heart rate and arterial pressure in patients undergoing endotracheal intubation receiving 0.5 µg/kg dexmedetomidine versus 1.00 µg/kg dexmedetomidine.Study Design: Randomized control trial.Place and Duration of Study: The study was conducted in main Operation Theatre of Combined Military Hospital Sialkot, Pakistan from 3rd February 2022 to 30th November 2022.Material and Methods:  A total of 60 patients undergoing elective surgeries under general anesthesia using endotracheal intubation, aged 20 – 60 years of either gender were included. The included patients were divided into two groups using draw randomization. Randomization was done using lottery method. Group I patients received 0.5 µg/kg dexmedetomidine infusion and group II patients received 1.0 µg/kg dexmedetomidine infusion over 10 mins through a controlled infusion device. After endotracheal intubation, mean arterial pressure (MAP) and mean heart rate (HR) were noted after 3 minutes of intubation. Non-probability convenience sampling was used for date collection and SPSS version 23 was used for data analysis.Result: Out of 60 patients, 26 (43.33%) were males and 34 (56.67%) were females with male to female ratio of 1:1.3, the average age was 42.19 ± 9.87 years and BMI was found 28.88 ± 2.48 kg/m2. In group I (0.5 µg/kg dexmedetomidine infusion), the mean HR and MAP before intubation was 108.43 ± 6.26 bpm, 112.20 ± 8.88 mmHg and after 3 minutes of intubation was 76.20 ± 4.16 bpm, 88.20 ± 3.93 respectively while in group II (1.0 µg/kg dexmedetomidine infusion), the mean HR and MAP before intubation 102.10 ± 10.20 bpm, 109.07 ± 8.35 mmHg and after 3 minutes of intubation was 85.97 ± 3.26 bpm, 97.90 ± 5.74 mmHg respectively.Conclusion: Higher dose of dexmedetomidine (1.0 ug/kg) significantly attenuates hemodynamic response on endotracheal intubation as compare to lower dose (0.5 µg/kg).