65岁以上人群认知障碍与慢性心力衰竭之间的关系:来自俄罗斯多中心研究EUCALYPTUS的数据

Q4 Medicine

Arterial Hypertension (Russian Federation) Pub Date : 2023-05-02 DOI:10.18705/1607-419x-2023-29-3-275-285

A. Izyumov, N. M. Vorobyova, H. A. Mkhitaryan, K. Eruslanova, Y. Kotovskaya, O. Tkacheva

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引用次数: 0

摘要

目标。本研究的目的是研究≥65岁人群中认知障碍(CI)和慢性心力衰竭(CHF)的患病率，并分析两者之间的关系。设计和方法。在多中心EUCALYPTUS研究的亚分析中，选择了3537名年龄在65至107岁(平均年龄78,7±8,4岁)的患者，他们有关于CHF存在/不存在的信息，并接受了Mini- Cog测试。所有患者分为2组:存在(n = 2111)和不存在(n = 1426) chf。该样本中CHF患病率为59.7%，CI - 60.08%。随着年龄的增长，CHF和CI的患病率均显著增加。CHF患者的平均年龄比非CHF患者大4岁，但没有性别差异。总的来说，CHF患者可能CI (Mini-Cog试验≤3点)的频率显著高于非CHF患者(64,5% против 55,4%;P < 0.001)。单因素回归分析表明，Mini-Cog测试积分每增加1分，发生CHF的几率降低14%，可能CI的存在与发生CHF的几率增加46%相关。单因素回归分析显示，与没有CI(参考分类;优势比= 1,0)，CI患者发生CHF的几率增加72%，而中度CI风险的存在与发生CHF的几率增加无关。然而，当在模型中调整年龄和性别时，由于年龄与CHF和ci均显著相关，上述所有关联都失去了意义。因此，一项多中心的EUCALYPTUS研究结果表明，在俄罗斯人群中，老年人和老年人中可能的CI和CHF的患病率很高，以及它们之间的关系。

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Associations between cognitive impairment and chronic heart failure in people over the age of 65: data from the Russian multicenter study EUCALYPTUS

Objective. The aim of the study was to study the prevalence of cognitive impairment (CI) and chronic heart failure (CHF) in people aged ≥ 65 years, as well as to analyze the relationship between them.Design and methods. In the subanalysis of the multicenter EUCALYPTUS study, 3537 patients aged 65 to 107 years (average age 78,7 ± 8,4 years) were selected who had information about the presence/absence of CHF and who underwent a Mini- Cog test. All patients were stratified into 2 groups: with the presence (n = 2111) and absence (n = 1426) of CHF.Results. The prevalence of CHF in this sample was 59,7 %, CI — 60,8 %. With increasing age, the prevalence of both CHF and CI increased significantly. Patients with CHF were on average 4 years older than patients without CHF, but did not differ by gender. In general, the frequency of probable CI (≤ 3 points in the Mini-Cog test) in patients with CHF was significantly higher than without CHF (64,5 % против 55,4 %; p < 0,001). One-factor regression analysis demonstrated that an increase in the sum of points in the Mini-Cog test for every 1 point reduces the chances of having CHF by 14 %, and the presence of probable CI is associated with an increase in the chances of having CHF by 46 %. Univariate regression analysis showed that compared with the absence of CI (reference category; odds ratio = 1,0), patients with CI had a 72 % higher chance of having CHF, whereas the presence of a moderate risk of CI was not associated with an increased chance of having CHF. However, when adjusting for age and gender in the model, all of the above associations lost their significance due to the fact that age is significantly associated with both CHF and CI.Conclusions. Thus, the results of a multicenter study of EUCALYPTUS demonstrate a high prevalence of both probable CI and CHF among the elderly and senile in the Russian population and their relationship.

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来源期刊

Arterial Hypertension (Russian Federation) Medicine-Cardiology and Cardiovascular Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication. The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.