妊娠与非妊娠育龄妇女因COVID-19感染住院的比较

Q3 Medicine

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI:10.52142/omujecm.39.4.46

Özgür Kılıç, M. Polat, Nazmiye TİBEL TUNA, Eda Köprü, M. Elmalı, İlkay Bozkurt, D. Güven, M. Dilek

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引用次数: 0

摘要

COVID-19对孕妇的影响比育龄非孕妇更严重。然而，其他研究报告的危重疾病和死亡率在两组中差异很大。本研究旨在了解入院的妊娠和非妊娠匹配对照患者的COVID-19临床结局。2020年3月11日至12月11日在土耳其萨姆松Ondokuz Mayis大学医院住院的感染COVID-19的怀孕和非怀孕育龄患者(18-45岁)被纳入研究。回顾性分析患者的临床、放射学和实验室资料。共调查153例患者，其中123例未怀孕，30例怀孕。5名(17%)孕妇因与COVID-19相关的急性呼吸衰竭而发生紧急分娩，1名(3%)孕妇因产科原因发生紧急分娩。报告有4例早产，1例围产期死亡，无死产或流产。妊娠期重症监护病房(ICU)住院率[7/30 (23.3%)vs 3/123 (2.4%)， p<0.001]和有创机械通气(IMV)需求[5/30 (17.0%)vs 2/123 (1.6%)， p=0.003]显著高于非妊娠期患者。然而，住院时间(HLOS)和死亡率在两组之间没有差异:HLOS的中位数为4天vs 5天，p=0.68，死亡率分别为1/123 (0.8%)vs 0/30 (0%)， p=0.62。我们观察到，与未怀孕的对照组相比，孕妇的COVID-19病程更严重，但在住院时间和死亡率方面没有发现差异。研究发现，在全球范围内，住院的怀孕或非怀孕育龄妇女的COVID-19总病死率远低于一般住院人口。版权所有©2022 Ondokuz Mayis Universitesi。版权所有。

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Comparison of the pregnant and non-pregnant women of reproductive age hospitalized due to COVID-19 infection

COVID-19 affects pregnant women more severely than nonpregnant women of reproductive age. However, the rate of critical illness and fatality reported in other studies varied in a wide range in both groups. The study aims to investigate the clinical outcomes of COVID-19 in the pregnant and nonpregnant matched control patients admitted to the hospital. Pregnant and nonpregnant patients of reproductive age (18-45 years) infected with COVID-19 who were admitted to Ondokuz Mayis University Hospital, Samsun, Turkey, from March 11 to December 11, 2020, were enrolled in the study. The clinical, radiological, and laboratory data of the patients were analyzed retrospectively. A total of 153 patients were investigated;123 were nonpregnant, and 30 were pregnant. Emergency delivery occurred in 5 (17%) pregnant women due to acute respiratory failure associated with COVID-19 and 1 (3%) pregnant woman due to obstetric reasons. Four premature births, one perinatal death, and no stillbirth or miscarriage were reported. The rate of admission to the intensive care unit (ICU) [7/30 (23.3%) vs 3/123 (2.4%), p<0.001] and the need for invasive mechanical ventilation (IMV) [5/30 (17.0%) vs 2/123 (1.6%), p=0.003] were significantly higher in pregnant than in non-pregnant patients. However, hospital length of stay (HLOS) and mortality did not differ between groups: HLOS was median 4 vs 5 days, p=0.68, and the mortality rate was 1/123 (0.8%) vs 0/30 (0%), p=0.62 in nonpregnant and pregnant patients respectively. We observed that COVID-19 has a more severe course in pregnant women versus the nonpregnant control group, but no difference was noted in terms of hospital length of stay and mortality. The overall case fatality rate of COVID-19 in hospitalized pregnant or nonpregnant women of reproductive age was found to be much lower than the general hospitalized population worldwide. Copyright © 2022 Ondokuz Mayis Universitesi. All rights reserved.

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来源期刊

Tokai Journal of Experimental and Clinical Medicine Medicine-Medicine (all)

CiteScore

1.10

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0.00%

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期刊介绍： The Tokai Journal of Experimental and Clinical Medicine, also referred to as Tokai Journal, is an official quarterly publication of the Tokai Medical Association. Tokai Journal publishes original articles that deal with issues of clinical, experimental, socioeconomic, cultural and/or historical importance to medical science and related fields. Manuscripts may be submitted as full-length Original Articles or Brief Communications. Tokai Journal also publishes reviews and symposium proceedings. Articles accepted for publication in Tokai Journal cannot be reproduced elsewhere without written permission from the Tokai Medical Association. In addition, Tokai Journal will not be held responsible for the opinions of the authors expressed in the published articles.