{"title":"石棉暴露与睾丸阴道膜恶性间皮瘤:病例系列及文献回顾","authors":"C. Meisenkothen, M. Finkelstein","doi":"10.13172/2052-0077-2-2-424","DOIUrl":null,"url":null,"abstract":"Introduction During normal human embryonic development, the testes descend from the abdominal cavity to the scrotal sac. Passage occurs through the processus vaginalis, which arises as an outpouching of the parietal peritoneum at the beginning of the third month of gestation. After the testis descends into the scrotum (between 7 and 9 months of gestation), the processus vaginalis is normally obliterated. However, the processus vaginalis remains patent at birth in 20% of the population. Most boys born with a patent processus vaginalis remain asymptomatic throughout life, but incomplete closure of the processus vaginalis may lead to a variety of abnormalities. Complete patency may result in a communicating hydrocele or a congenital i nguinoscrotal hernia. A persistent processus vaginalis often closes during the first year of life, probably in response to the surge in serum testosterone that normally occurs at 1–2 months of age1. The tunica vaginalis is a mesotheliumlined sac that results from closure of the superior portion of the processus vaginalis. In the event that the processus vaginalis does not close completely, then the tunica vaginalis remains in communication with the peritoneal cavity. Mesothelioma of the tunica vaginalis is a rare tumour. In a study of incident cases of mesothelioma in the Netherlands, most of the mesotheliomas occurred in the pleura, where there were 119 (88%) against 15 (11%) in the peritoneum and two in the tunica vaginalis testis2. Marinaccio and colleagues3 reported on the incidence of extrapleural mesothelioma in the Italian National Mesothelioma Registry. Standardized incidence rates (Italy, 2004, per million inhabitants) were 2.1 cases for the peritoneal site and 0.2 cases for the tunica vaginalis testis. Mesothelioma of the tunica vaginalis represents only 0.09% (10 cases) of all mesothelioma deaths in the UK Health and Safety Executive Mesothelioma Register4. Mesothelioma of the tunica vaginalis has been associated with asbestos exposure. The first case report was published by Fligiel and Kaneko in 19765. The subject, a 68-year-old man, had worked for 40 years as a pipe insulator. Gorini and colleagues6 in Italy reported two cases of this tumour. A 67-year-old man had been occupationally exposed to asbestos for a 30-year period with a latency of 42 years. An 80-year-old man had been exposed to asbestos for 5 years with a latency of 52 years. Spiess and colleagues reported a retrospective clinicopathological and follow-up study of five patients with malignant mesothelioma of the tunica vaginalis treated at the M.D. Anderson Cancer Center in Houston, Texas, during a 25year period7. Asbestos exposure was identified in four of the five patients. In the Italian Registry Study3, 70% of subjects with mesothelioma of the tunica vaginalis had occupational or leisure-related exposure to asbestos. Mean latency (defined as the time elapsing between the beginning of exposure to asbestos and diagnosis) was estimated for cases with sufficient information and was 46.8 years * Corresponding author Email: cmeisenkothen@elslaw.com","PeriodicalId":19393,"journal":{"name":"OA Case Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: Case series and review of the literature\",\"authors\":\"C. Meisenkothen, M. Finkelstein\",\"doi\":\"10.13172/2052-0077-2-2-424\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction During normal human embryonic development, the testes descend from the abdominal cavity to the scrotal sac. Passage occurs through the processus vaginalis, which arises as an outpouching of the parietal peritoneum at the beginning of the third month of gestation. After the testis descends into the scrotum (between 7 and 9 months of gestation), the processus vaginalis is normally obliterated. However, the processus vaginalis remains patent at birth in 20% of the population. Most boys born with a patent processus vaginalis remain asymptomatic throughout life, but incomplete closure of the processus vaginalis may lead to a variety of abnormalities. Complete patency may result in a communicating hydrocele or a congenital i nguinoscrotal hernia. A persistent processus vaginalis often closes during the first year of life, probably in response to the surge in serum testosterone that normally occurs at 1–2 months of age1. The tunica vaginalis is a mesotheliumlined sac that results from closure of the superior portion of the processus vaginalis. In the event that the processus vaginalis does not close completely, then the tunica vaginalis remains in communication with the peritoneal cavity. Mesothelioma of the tunica vaginalis is a rare tumour. In a study of incident cases of mesothelioma in the Netherlands, most of the mesotheliomas occurred in the pleura, where there were 119 (88%) against 15 (11%) in the peritoneum and two in the tunica vaginalis testis2. Marinaccio and colleagues3 reported on the incidence of extrapleural mesothelioma in the Italian National Mesothelioma Registry. Standardized incidence rates (Italy, 2004, per million inhabitants) were 2.1 cases for the peritoneal site and 0.2 cases for the tunica vaginalis testis. Mesothelioma of the tunica vaginalis represents only 0.09% (10 cases) of all mesothelioma deaths in the UK Health and Safety Executive Mesothelioma Register4. Mesothelioma of the tunica vaginalis has been associated with asbestos exposure. The first case report was published by Fligiel and Kaneko in 19765. The subject, a 68-year-old man, had worked for 40 years as a pipe insulator. Gorini and colleagues6 in Italy reported two cases of this tumour. A 67-year-old man had been occupationally exposed to asbestos for a 30-year period with a latency of 42 years. An 80-year-old man had been exposed to asbestos for 5 years with a latency of 52 years. Spiess and colleagues reported a retrospective clinicopathological and follow-up study of five patients with malignant mesothelioma of the tunica vaginalis treated at the M.D. Anderson Cancer Center in Houston, Texas, during a 25year period7. Asbestos exposure was identified in four of the five patients. In the Italian Registry Study3, 70% of subjects with mesothelioma of the tunica vaginalis had occupational or leisure-related exposure to asbestos. Mean latency (defined as the time elapsing between the beginning of exposure to asbestos and diagnosis) was estimated for cases with sufficient information and was 46.8 years * Corresponding author Email: cmeisenkothen@elslaw.com\",\"PeriodicalId\":19393,\"journal\":{\"name\":\"OA Case Reports\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"OA Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.13172/2052-0077-2-2-424\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"OA Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13172/2052-0077-2-2-424","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: Case series and review of the literature
Introduction During normal human embryonic development, the testes descend from the abdominal cavity to the scrotal sac. Passage occurs through the processus vaginalis, which arises as an outpouching of the parietal peritoneum at the beginning of the third month of gestation. After the testis descends into the scrotum (between 7 and 9 months of gestation), the processus vaginalis is normally obliterated. However, the processus vaginalis remains patent at birth in 20% of the population. Most boys born with a patent processus vaginalis remain asymptomatic throughout life, but incomplete closure of the processus vaginalis may lead to a variety of abnormalities. Complete patency may result in a communicating hydrocele or a congenital i nguinoscrotal hernia. A persistent processus vaginalis often closes during the first year of life, probably in response to the surge in serum testosterone that normally occurs at 1–2 months of age1. The tunica vaginalis is a mesotheliumlined sac that results from closure of the superior portion of the processus vaginalis. In the event that the processus vaginalis does not close completely, then the tunica vaginalis remains in communication with the peritoneal cavity. Mesothelioma of the tunica vaginalis is a rare tumour. In a study of incident cases of mesothelioma in the Netherlands, most of the mesotheliomas occurred in the pleura, where there were 119 (88%) against 15 (11%) in the peritoneum and two in the tunica vaginalis testis2. Marinaccio and colleagues3 reported on the incidence of extrapleural mesothelioma in the Italian National Mesothelioma Registry. Standardized incidence rates (Italy, 2004, per million inhabitants) were 2.1 cases for the peritoneal site and 0.2 cases for the tunica vaginalis testis. Mesothelioma of the tunica vaginalis represents only 0.09% (10 cases) of all mesothelioma deaths in the UK Health and Safety Executive Mesothelioma Register4. Mesothelioma of the tunica vaginalis has been associated with asbestos exposure. The first case report was published by Fligiel and Kaneko in 19765. The subject, a 68-year-old man, had worked for 40 years as a pipe insulator. Gorini and colleagues6 in Italy reported two cases of this tumour. A 67-year-old man had been occupationally exposed to asbestos for a 30-year period with a latency of 42 years. An 80-year-old man had been exposed to asbestos for 5 years with a latency of 52 years. Spiess and colleagues reported a retrospective clinicopathological and follow-up study of five patients with malignant mesothelioma of the tunica vaginalis treated at the M.D. Anderson Cancer Center in Houston, Texas, during a 25year period7. Asbestos exposure was identified in four of the five patients. In the Italian Registry Study3, 70% of subjects with mesothelioma of the tunica vaginalis had occupational or leisure-related exposure to asbestos. Mean latency (defined as the time elapsing between the beginning of exposure to asbestos and diagnosis) was estimated for cases with sufficient information and was 46.8 years * Corresponding author Email: cmeisenkothen@elslaw.com