HucMSC-Ex通过lnc78583介导的miR3202/HOXB13途径缓解炎症性肠病

IF 4.7 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Zhejiang University SCIENCE B Pub Date : 2022-05-01 DOI:10.1631/jzus.B2100793

Yuting Xu, Li Zhang, D. K. W. Ocansey, Bo Wang, Yilin Hou, Rong Mei, Yongmin Yan, Xu Zhang, Zhaoyang Zhang, F. Mao

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引用次数: 3

摘要

炎症性肠病(inflammatory bowel disease, IBD)作为一组影响肠道的非特异性炎症性疾病，具有慢性复发性炎症的特点，且已被证实发病率呈上升趋势(Kaplan, 2015)。由遗传背景、环境变化、免疫功能、微生物组成和毒素暴露诱发的IBD (Sasson等，2021)主要包括溃疡性结肠炎(UC)和克罗恩病(CD)，临床症状复杂，以腹痛、腹泻甚至便血为特征(Fan等，2021;黄等人，2021)。UC主要局限于直肠和结肠，而CD通常以不连续的方式影响回肠末端和结肠(Ordás et al.， 2012;pansams and Rimola, 2017)。近年来，许多研究表明，在IBD的诊断和治疗方面缺乏有效的措施，迫切需要新的策略来了解IBD的机制并提供有希望的治疗方法。

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HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway

As a group of nonspecific inflammatory diseases affecting the intestine, inflammatory bowel disease (IBD) exhibits the characteristics of chronic recurring inflammation, and was proven to be increasing in incidence (Kaplan, 2015). IBD induced by genetic background, environmental changes, immune functions, microbial composition, and toxin exposures (Sasson et al., 2021) primarily includes ulcerative colitis (UC) and Crohn's disease (CD) with complicated clinical symptoms featured by abdominal pain, diarrhea, and even blood in stools (Fan et al., 2021; Huang et al., 2021). UC is mainly limited to the rectum and the colon, while CD usually impacts the terminal ileum and colon in a discontinuous manner (Ordás et al., 2012; Panés and Rimola, 2017). In recent years, many studies have suggested the lack of effective measures in the diagnosis and treatment of IBD, prompting an urgent need for new strategies to understand the mechanisms of and offer promising therapies for IBD.

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来源期刊

Journal of Zhejiang University SCIENCE B 生物-生化与分子生物学

CiteScore

8.70

自引率

13.70%

发文量

2125

审稿时长

3.0 months

期刊介绍： Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community. JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.