奥罗米亚地区州二级和三级护理医院接受高活性抗逆转录病毒治疗的艾滋病毒/艾滋病患者住院和住院死亡率的原因和预测因素:多中心横断面研究

IF 0.3 Q4 INFECTIOUS DISEASES
G. Umeta, Legese Chelkeba, Gosaye Mekonen Tefera, Kemal Jemal, K. K. Goro
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引用次数: 0

摘要

高效抗逆转录病毒疗法(HAART)显著降低了获得性免疫缺陷综合征(AIDS)的发病率、发病率和死亡率。然而,目前的研究表明,艾滋病患者的住院率有所上升。因此,本研究旨在确定接受HAART治疗的人类免疫缺陷病毒(HIV)/艾滋病感染患者住院和住院死亡率的原因和预测因素。材料和方法:这是一项多中心横断面研究,纳入了2017年5月1日至2017年8月30日在奥罗米亚地区州二级和三级护理医院住院的艾滋病毒/艾滋病患者。采用结构化检查表和访谈法对住院的HIV/AIDS患者进行数据收集。结果用社会科学统计软件包(SPSS)软件,版本22进行分析。采用双变量和多变量logistic回归分析评价相关性,采用p值< 0.05判断因变量与自变量之间的关系。结果:171名参与者中,105名(61%)因机会性感染住院。年龄40 ~ 49岁(AOR = 0.30;95% CI: 0.09-0.98%) vs. 18-29,女性(AOR = 2.41;95% CI: 1.11-5.24%), CD4+计数小于200 (AOR = 10.32;95% CI: 3.49 ~ 30.52%),粘附不良(AOR = 2.78;95% CI: 1.21-6.41%)与因机会性感染(艾滋病相关疾病)住院显著相关。入院患者中死亡20例(11.7%)。依从性差和住院时间大于等于9天的患者更容易发生院内死亡,AOR = 3.093;95% CI: 1.012-9.453%, AOR = 4.533;95% CI分别为1.371-14.985%。结论:住院的主要原因是HIV/ aids相关疾病。必须遵守艾滋病毒药物治疗方案,以尽量减少因机会性感染住院和艾滋病毒/艾滋病死亡率。HIV / AIDS Rev 2021;DOI: https://doi.org/10.5114/hivar.2021.107236
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Causes and predictors of hospitalization and in-hospital mortality among HIV/AIDS patients on highly active antiretroviral therapy in secondary and tertiary care hospitals in Oromia Regional State: multi-center cross-sectional study
Introduction: Highly active antiretroviral therapies (HAART) decrease the incidence, morbidity, and mortality of acquired immunodeficiency syndrome (AIDS) dramatically. However, current research reported an increased hospitalization rate among AIDS patients. Therefore, this study aimed to determine causes and predictors of hospital admission as well as in-hospital mortality amongst human immunodeficiency virus (HIV)/AIDS-infected patients on HAART. Material and methods: This was a multi-center cross-sectional study, and included HIV/AIDS patients who were admitted to secondary and tertiary care hospitals in Oromia Regional State from May 1, 2017, to August 30, 2017. Data were collected from hospitalized HIV/AIDS patients using structured checklist and interview. Results were analyzed with Statistical Package for Social Sciences (SPSS) software, version 22. Bivariate and multivariable logistic regression analysis were performed to evaluate association, and p-value < 0.05 was used to determine relationship between dependent and independent variables. Results: Out of 171 participants enrolled, 105 (61%) were hospitalized due to opportunistic infections. Age ranged from 40 to 49 (AOR = 0.30; 95% CI: 0.09-0.98%) vs. 18-29, females (AOR = 2.41; 95% CI: 1.11-5.24%), CD4+ count less than 200 (AOR = 10.32; 95% CI: 3.49-30.52%), and poor adhered (AOR = 2.78; 95% CI: 1.21-6.41%) were significantly related to hospitalization with opportunistic infections (AIDS-related illnesses). Among admitted patients, 20 (11.7%) died in hospital. Poorly adherent patients and those who spent 9 days or more in hospital were more exposed to in-hospital death, with AOR = 3.093; 95% CI: 1.012-9.453% and AOR = 4.533; 95% CI: 1.371-14.985%, respectively. Conclusions: The major causes of hospitalization were HIV/AIDS-related illnesses. Adherence to the HIV drug regimen is warranted to minimize hospitalization with opportunistic infections and HIV/AIDS mortality. HIV AIDS Rev 2021; 20, 2: 102-108 DOI: https://doi.org/10.5114/hivar.2021.107236
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HIV & AIDS Review
HIV & AIDS Review INFECTIOUS DISEASES-
CiteScore
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30
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12 weeks
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