通过肌动蛋白信号调节脊柱的形成和功能

H. Okada, S. Soderling
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引用次数: 6

摘要

最近的进展极大地扩展了我们对信号通路如何调节突触后棘中的肌动蛋白细胞骨架的看法。这些研究揭示了在脊柱发育过程中肌动蛋白对骨骼的作用以及对改变突触强度的刺激的反应,这些通路之间存在复杂的相互作用。本文综述了这些研究的结果,包括从生物化学、细胞和遗传学的角度来理解兴奋性突触的形成和功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Signaling Through Actin to Regulate Spine Formation and Function
Recent progress has greatly expanded our view of how signaling pathways regulate the actin cytoskeleton in post-synaptic spines. These studies reveal a complex interplay between pathways that highlight the role of the actin cy- toskeleton during the development of spines as well as in response to stimuli that modify synaptic strength. This review discusses the results from these studies that include biochemical, cellular, and genetic approaches to understanding excita- tory synapse formation and function.
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