尼日利亚哈科特港男性炼油厂工人血液学、凝血和免疫指标的评估

Ehiaghe-Shepherd, Bridget Obofoni, Christian, Serekara Gideon, Eze, Evelyn Mgbeoma
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引用次数: 0

摘要

目的:本研究的目的是评估尼日利亚哈科特港男性炼油厂工人的一些血液学、凝血和免疫参数的水平。研究设计:本研究为横断面研究。学习地点和时间:2021年1月至2021年9月,河流州立大学教学医院(RSUTH),哈科特港,尼日利亚壳牌石油开发公司有限公司和河流州立模块化炼油厂。方法:共纳入100名受试者(50名油气工人为测试对象,50名非油气工人为对照对象)。本研究采用方便抽样技术。采集所有受试者静脉血,检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原浓度、全血细胞计数(FBC)(血红蛋白(Hb)、堆积细胞体积(PCV)、白细胞总数(WBC)、淋巴细胞、中性粒细胞、单核细胞和血小板计数)、CD4细胞计数、CD3细胞计数和CD8细胞计数。生成的数据使用Graph-Pad Prism, Version 8.0.2进行统计分析。结果:炼油厂工人接触天然气火炬后凝血酶原时间(PT)(11.55±0.73s)、国际标准化比值(INR)(0.85±0.05)、纤维蛋白原(202.4±27.4mg/dl)、血小板计数(185.6±37.1(103/μl))、中性粒细胞(46.6±6.4%)下降有统计学意义(P< 0.001), APTT(31.8±4.15s)、Hb(13.7±1.0g/dl)、PCV(41.1±3.2%)、在凝血酶原时间(12.23±0.82s)、INR(0.90±0.06)、纤维蛋白原(252.0±57.0mg/dl)、血小板计数(213.3±49.5(103/μl))和中性粒细胞(52.6±11.7%)方面,气体火炬暴露组的单核细胞(8.4±3.0%)高于对照组。其他参数差异无统计学意义(P<)。实验组和对照组均为0.05。用方差分析比较被试年龄的研究参数的均数±标准差,各参数差异无统计学意义,P< 0.05。采用方差分析方法比较暴露时间对被试各项参数的均值±标准差,发现CD8细胞随着暴露时间的增加而显著降低(2-5年暴露= 865±319,6-10年暴露= 579±288,11-20年暴露= 591±286,F值= 3.869,P值= 0.0278)。结论:综上所述,男性炼油工人的血液学、凝血学和免疫指标有些升高,有些降低,暴露时间也可能是导致研究参数畸变的危险因素,而年龄不是导致畸变的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Some Haematological, Coagulation and Immune Parameters among Male Oil Refinery Workers in Port Harcourt, Nigeria
Aim: The aim of this study was to assess the levels of some hematological, coagulation and immune parameters among male oil refinery workers in Port Harcourt, Nigeria. Study Design: This study is a cross-sectional study. Place and Duration of Study: Rivers State University Teaching Hospital (RSUTH), Port Harcourt, Shell Petroleum Development Company of Nigeria Limited and Modular Oil Refinery, Rivers State, between January 2021 and September 2021. Methodology: A total of one hundred (100) subjects (50 oil and gas workers as test subjects and 50 non-oil and gas workers as control subjects), were enrolled in the study. The convenient sampling technique was employed in the study. Venous blood samples were collected from all subjects and tested for Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen concentration, Full Blood Count (FBC) (Haemoglobin (Hb), Packed Cell Volume (PCV), Total White Blood Cell (WBC) count, Lymphocyte, Neutrophils, monocytes and Platelet Count), CD4 cell count, CD3 cell count and CD8 cell count. Data generated were analyzed statistically using Graph-Pad Prism, Version 8.0.2. Results: There was statistically significant decrease (P<.001) in Prothrombin time (PT) (11.55±0.73s), International Normalized Ratio (INR) (0.85±0.05), Fibrinogen (202.4±27.4mg/dl), Platelet count (185.6±37.1(103/μl)) and Neutrophils (46.6±6.4%) in oil refinery workers exposed to gas flare, while there was a statistical significant increase in APTT (31.8±4.15s), Hb (13.7±1.0g/dl), PCV (41.1±3.2%), Monocytes (8.4±3.0%) in subjects exposed to gas flare over control subjects with Prothrombin time(12.23±0.82s), INR(0.90±0.06), Fibrinogen(252.0±57.0mg/dl), platelet count(213.3±49.5(103/μl)) and Neutrophils(52.6±11.7%). Other parameters showed no statistical significant difference at P<.05 in both test and control subjects. Comparison of the mean ± standard deviation of the studied parameters in test subjects based on age using Analysis of Variance showed no statistically significant difference in all parameters at P<.05. Also, Comparison of the mean ± standard deviation of the studied parameters in test subjects based on duration of Exposure using Analysis of Variance showed a significant decrease in CD8 cells as the years of exposure increase (2-5years exposure = 865±319, 6-10years exposure = 579±288, 11-20 years exposure = 591± 286, F- Value = 3.869, P- Value = 0.0278). Conclusion: In conclusion, based on the findings, some haematogical, coagulation and immune parameters increased while others decreased in male oil refinery workers and duration of exposure can also be considered as a risk factor and age was considered not a risk factor as to cause any aberrations in the studied parameters.
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