骨化三醇水平与儿童慢性肾病分期的关系

IF 0.2 Q4 PEDIATRICS
Diska Yulia Trisiana, F. F. Yani, Fitrisia Amelin, Aumas Pabuti
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引用次数: 0

摘要

背景:慢性肾脏疾病(CKD)的肾脏损害扰乱了1?-羟化酶,阻止维生素D转化为活性形式的骨化三醇。据我们所知,之前没有研究评估过CKD患儿骨化三醇水平。维生素D水平降低可能发生在疾病的早期阶段,因此评估早期CKD儿童骨化三醇水平很重要。目的评价CKD患儿骨化三醇水平与疾病分期及其他特征的关系。方法本横断面研究对印度尼西亚巴东Dr. M Djamil医院的43例儿童CKD患者进行了研究。我们记录了患者的特征并进行了实验室检查,包括常规血液学、血尿素氮(BUN)、肌酐、尿酸、电解质、钙和骨化三醇水平。根据估计的肾小球滤过率(GFR),将患者分为早期(I期和II期)或晚期(III期至V期)CKD。进行了单因素和多因素分析,以确定骨化三醇水平与疾病分期和其他特征之间的关系。结果各组骨化三醇平均水平为108.77 (SD 10.79) pmol/L。I ~ V期CKD的平均水平分别为164.28 (SD 160.90)、94.14 (SD 50.63)、72.16 (SD 13.18)、62.92 (SD 4.87)和67.51 (SD 4.87) pmol/L。骨化三醇水平在CKD分期中差异无统计学意义(P=0.114)。骨化三醇水平因生长特征(P=0.944)、病因(P=0.311)或贫血状态(P=0.104)而无显著差异。然而,与63.6%的早期CKD患者相比,所有晚期CKD患者骨化三醇水平均较低(P=0.004)。与ⅰ期相比,ⅳ期(P=0.049)和ⅴ期(P=0.027)骨化三醇平均水平显著降低。结论骨化三醇水平降低发生在CKD早期。骨化三醇水平在晚期明显低于早期CKD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Calcitriol levels and the stage of chronic kidney disease in children
Background Kidney damage in chronic kidney disease (CKD) disrupts the 1?-hydroxylase enzyme, preventing the conversion of vitamin D into the active form of calcitriol. To our knowledge, no previous studies have assessed calcitriol levels in children with CKD. Decreased vitamin D levels may occur at an early stage of the disease, so it is important to evaluate calcitriol levels in children with early stage CKD. Objective To assess calcitriol levels in children with CKD according to disease stage and other characteristics. Methods This cross-sectional study was conducted on 43 pediatric CKD patients at Dr. M Djamil Hospital, Padang, Indonesia. We recorded patient characteristics and performed laboratory tests, including routine hematology, blood urea nitrogen (BUN), creatinine, uric acid, electrolytes, calcium, and calcitriol levels. Based on estimated glomerular filtration rate (GFR), patients were grouped into either early-stage (stages I and II), or advanced-stage (stages III to V) CKD. Univariate and multivariate analyses were conducted to determine the association between calcitriol levels with disease stage and other characteristics. Results The overall mean calcitriol level of our subjects was 108.77 (SD 10.79) pmol/L. Mean levels at each CKD stage from I to V were 164.28 (SD 160.90), 94.14 (SD 50.63), 72.16 (SD 13.18), 62.92 (SD 4.87), and 67.51 (SD 4.87) pmol/L, respectively. Calcitriol levels did not differ significantly by CKD stage (P=0.114) when each stage from I to V was considered separately. There was no significant difference in calcitriol levels by growth characteristics (P=0.944), etiology (P=0.311), or anemic status (P=0.104). However, low calcitriol levels were found in all subjects with advanced stage CKD, compared to 63.6% subjects with early stage CKD  (P=0.004). Mean calcitriol levels were significantly lower in CKD stage IV (P=0.049) and stage V (P=0.027) compared to stage I. Conclusions The decrease in calcitriol level occurs at an early stage in CKD. Calcitriol levels are significantly lower in advanced stage than in early stage CKD.
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来源期刊
CiteScore
0.40
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0.00%
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58
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24 weeks
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