COVID-19大流行:药物消费的变化及其对治疗策略的影响

M. Kara, Esma Yıldırım
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引用次数: 0

摘要

目的:本研究旨在通过检查开塞利市培训和研究医院在COVID-19大流行期间与COVID-19前期间的药物消费变化,建立未来潜在大流行情景下的药物供应路线图。材料和方法:本研究对疫情前后一年的药品库存数据进行了分析。确定大流行开始日期为2020年4月,即第一例COVID-19病例入住我院的日期。药品库存投入和产出数据来自医院信息管理系统。数据以每月住院人数为单位,以百分比计算。调查的药物组包括抗病毒、抗生素、降压、降糖、抗真菌、抗血栓、止咳和精神药物。具体来说,最常用的抗真菌药物被确定为脂质体两性霉素B、氟康唑、甲硝唑、卡泊真菌素和制霉菌素;降压药包括氨氯地平、培哚普利、卡维地洛和速尿;抗糖尿病药物包括甘精胰岛素、天冬氨酸胰岛素、甘氨酸胰岛素和盐酸二甲双胍;精神科药物包括喹硫平、艾司西酞普兰、舍曲林;抗病毒药物为法匹拉韦、奥司他韦和瑞德西韦;抗生素包括氨苄西林钠、头孢曲松、左氧氟沙星、莫西沙星和克拉霉素。此外,在我院大流行期间,依诺肝素钠被用作抗血栓剂,左旋丙哌嗪被用作止咳剂。结果:与covid - 19前相比,所有药物组的每位患者的药物供应数量都有所增加。然而,在大流行期间的某些月份,呋塞米、卡维地洛、甲硝唑、两性霉素B脂质体、喹硫平和二甲双胍的使用率有所下降。使用率最高的药物类别为抗血栓药、抗病毒药物和抗生素。值得注意的是,抗血栓药物的消耗量在大流行的第一年增加了270倍。结论:正如我们的研究结果所表明的那样,本研究强调了大流行期间药物消费和需求的潜在变化,特别是在抗菌和抗血栓药物的情况下。它强调了采取积极措施调整药品供应以满足关键时期诊所和住院服务需求的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 Pandemic: Changes in Drug Consumption and Implications for Treatment Strategies
Objective: This study aims to establish a roadmap for drug supply during potential future pandemic scenarios by examining the variations in drug consumption at Kayseri City Training and Research Hospital during the COVID-19 pandemic compared to the pre-COVID-19 period. Materials and Methods: The study involved an analysis of one-year drug stock data before and after the pandemic. The start date of the pandemic was identified as April 2020 when the first COVID-19 case was admitted to our hospital. Data on drug stock inputs and outputs were obtained from the Hospital Information Management System. The data were calculated as percentages by considering the number of inpatients on a monthly basis. The drug groups investigated included antiviral, antibiotic, antihypertensive, antidiabetic, antifungal, antithrombotic, antitussive, and psychiatric drugs. Specifically, the most commonly used antifungal agents were identified as liposomal amphotericin B, fluconazole, metronidazole, caspofungin, and nystatin; antihypertensive agents included amlodipine, perindopril, carvedilol, and furosemide; antidiabetic agents encompassed insulin glargine, insulin aspart, insulin glulisine, and metformin hydrochloride; psychiatric drugs consisted of quetiapine, escitalopram, and sertraline; antiviral agents were favipiravir, oseltamivir, and remdesivir; and antibiotics comprised ampicillin sodium, ceftriaxone, levofloxacin, moxifloxacin, and clarithromycin. Additionally, enoxaparin sodium was used as an antithrombotic agent, and levodropropizin as an antitussive during the pandemic at our hospital. Results: Comparing the pre-COVID period, an increase in the number of drugs supplied per patient was observed across all drug groups. However, the usage rates of furosemide, carvedilol, metronidazole, liposomal amphotericin B, quetiapine, and metformin decreased in certain months during the pandemic. The drug categories with the highest usage rates were antithrombotics, antivirals, and antibiotics. Notably, antithrombotic consumption increased by a factor of 270 in the first year of the pandemic. Conclusion: This study highlights the potential changes in drug consumption and requirements during pandemic periods, particularly in the case of antimicrobial and antithrombotic drugs, as demonstrated in our findings. It emphasizes the importance of proactive measures to adjust drug supply to meet the demands of clinics and inpatient services during critical periods.
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