{"title":"医院消毒人员羟乙基缬氨酸含量分析","authors":"Kai-Hsiang Huang , Su-Yin Chiang , Chia-Fang Wu , Lan-Tyi Duann , Tsung-Jen Cheng , Kuen-Yuh Wu","doi":"10.1016/j.gmbhs.2012.04.003","DOIUrl":null,"url":null,"abstract":"<div><p>The formation of N-(2-hydroxyethyl) valine (HEV) in hemoglobin has been considered as a biologically effective dose for exposures to ethylene oxide (EO). In this study, 148 volunteers with no EO exposure history and 76 EO-exposed hospital sterilization workers in Taiwan were recruited, 10<!--> <!-->ml of blood was collected, and background information was gathered using questionnaires from each study subject. HEV was processed by following the modified Edman degradation method and quantitated using a gas chirography coupled with mass spectrometry. Statistical analysis shows that the formation of HEV was significantly associated with smoking status and EO exposure.</p></div>","PeriodicalId":100577,"journal":{"name":"Genomic Medicine, Biomarkers, and Health Sciences","volume":"4 1","pages":"Pages 38-40"},"PeriodicalIF":0.0000,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmbhs.2012.04.003","citationCount":"0","resultStr":"{\"title\":\"Analysis of hydroxyethyl valine in hospital sterilization workers\",\"authors\":\"Kai-Hsiang Huang , Su-Yin Chiang , Chia-Fang Wu , Lan-Tyi Duann , Tsung-Jen Cheng , Kuen-Yuh Wu\",\"doi\":\"10.1016/j.gmbhs.2012.04.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The formation of N-(2-hydroxyethyl) valine (HEV) in hemoglobin has been considered as a biologically effective dose for exposures to ethylene oxide (EO). In this study, 148 volunteers with no EO exposure history and 76 EO-exposed hospital sterilization workers in Taiwan were recruited, 10<!--> <!-->ml of blood was collected, and background information was gathered using questionnaires from each study subject. HEV was processed by following the modified Edman degradation method and quantitated using a gas chirography coupled with mass spectrometry. Statistical analysis shows that the formation of HEV was significantly associated with smoking status and EO exposure.</p></div>\",\"PeriodicalId\":100577,\"journal\":{\"name\":\"Genomic Medicine, Biomarkers, and Health Sciences\",\"volume\":\"4 1\",\"pages\":\"Pages 38-40\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.gmbhs.2012.04.003\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genomic Medicine, Biomarkers, and Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211425412000118\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genomic Medicine, Biomarkers, and Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211425412000118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Analysis of hydroxyethyl valine in hospital sterilization workers
The formation of N-(2-hydroxyethyl) valine (HEV) in hemoglobin has been considered as a biologically effective dose for exposures to ethylene oxide (EO). In this study, 148 volunteers with no EO exposure history and 76 EO-exposed hospital sterilization workers in Taiwan were recruited, 10 ml of blood was collected, and background information was gathered using questionnaires from each study subject. HEV was processed by following the modified Edman degradation method and quantitated using a gas chirography coupled with mass spectrometry. Statistical analysis shows that the formation of HEV was significantly associated with smoking status and EO exposure.
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