目的:探讨镁和γ -谷氨酰转移酶在酒精性肝病中的作用

K. Gaikwad, S. Selkar, S. Agrawal
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引用次数: 1

摘要

目的:探讨镁和γ -谷氨酰转移酶在酒精性肝病中的作用。目的:(1)测定酒精性肝病患者血清镁和谷氨酰转移酶(GGT)水平。(2)评估酒精性肝病的肝酶:丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、总蛋白和白蛋白。(3)血清镁与所有肝酶的相关性。(4)血清GGT与所有肝酶的相关性。材料与方法:用Trivitron Dirui自动分析仪测定50例酒精性肝病患者和50例正常人的所有肝酶、血清镁、血清GGT、总蛋白和白蛋白。结果:Mg、GGT、AST、ALT、碱性磷酸酶、白蛋白平均值与对照组比较,差异有统计学意义(P0.05)。结论:慢性酒精性肝病显著升高γ -谷氨酰转移酶。低镁血症也见于酒精性肝病。酒精性肝病患者γ -谷氨酰转移酶与镁水平有显著关系。
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To study the role of magnesium and Gamma- glutamyl transferases in alcoholic liver disease
Aim: To study the role of magnesium and gamma- glutamyl transferases in alcoholic liver disease. Objectives: (1) To estimate serum magnesium and serum glutamyl-transferases (GGT) in alcoholic liver disease. (2) To estimate liver enzymes Alanine Transaminases (ALT), Aspartate Transaminases (AST), Alkaline Phosphatase (ALP), and Total protein and Albumin in alcoholic liver disease. (3) To correlate serum magnesium with all liver enzymes. (4) To correlate serum GGT with all liver enzymes. Materials and Methods: All liver enzymes, serum magnesium, serum GGT, total protein and albumin were estimated in 50 alcoholic liver disease patients and 50 normal subjects on Trivitron Dirui autoanalyzer. Results: Significant difference was found between mean values of cases and controls in Mg, GGT, AST, ALT, Alkaline phosphatase, and Albumin (P<0.05). Positive correlation was found between Mg with GGT, ALT, Total proteins and Albumin. This indicates that the higher(lower) values of Mg are associated with higher(lower) values of GGT, ALT, Total proteins, and Albumin. But the result were not statistically significant.(P >0.05). Conclusion: Chronic alcoholic liver disease significantly elevates Gamma-glutamyl transferase. Hypomagnesemia is also seen in alcoholic liver disease. Gamma-glutamyltransferase has a significant relation with magnesium levels in alcoholic liver disease.
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