聚丙烯酰胺-丙烯腈热敏微凝胶的制备及阿司匹林的控释

IF 2.5 4区医学 Q4 MATERIALS SCIENCE, BIOMATERIALS

International Journal of Polymeric Materials and Polymeric Biomaterials Pub Date : 2023-09-22 DOI:10.1080/00914037.2022.2090355

S. Cai, X. Li, Shijie Pu, Xinyu Ma, Xianru He

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引用次数: 1

摘要

摘要为了延长具有较高临界溶液温度(UCST)热响应行为的药物载体的释放时间，采用沉淀聚合法制备了P(AAm-co-AN)微凝胶。研究发现，当温度高于临界温度时，微凝胶表现出ucst型反应，微凝胶表现出良好的溶胀和分散性。由于微凝胶随着溶液温度的变化可以可逆地膨胀和收缩，因此可以用作药物载体。与胶束载体相比，微凝胶载体结构更稳定，缓释效果更好。图形抽象

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Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin

Abstract To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect. Graphical Abstract

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来源期刊

International Journal of Polymeric Materials and Polymeric Biomaterials Chemical Engineering-General Chemical Engineering

CiteScore

8.00

自引率

3.10%

发文量

审稿时长

3.3 months

期刊介绍： International Journal of Polymeric Materials and Polymeric Biomaterials is the official publication of the International Society for Biomedical Polymers and Polymeric Biomaterials (ISBPPB). This journal provides a forum for the publication of peer-reviewed, English language articles and select reviews on all aspects of polymeric materials and biomedical polymers. Being interdisciplinary in nature, this journal publishes extensive contributions in the areas of encapsulation and controlled release technologies to address innovation needs as well.