多巴胺激动剂在无功能垂体腺瘤治疗中的应用。

C. Capatina, C. Poiană
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引用次数: 1

摘要

无功能垂体瘤(NFPA)通常在诊断时很大,并表现出压迫邻近结构引起的症状。经蝶窦切除肿瘤是一线治疗方法,但在许多情况下,肿瘤不能完全切除。建议术后密切随访,反复进行激素评估和垂体成像。在肿瘤残余的随访中,有时使用放射治疗来阻止或阻止肿瘤的进展。药物治疗与多巴胺激动剂(DA)是主要的管理催乳素瘤。对于NFPA,一些小系列或病例报告表明,在某些情况下,肿瘤缩小有益。本文的目的是总结与DA药物治疗NFPA潜在疗效相关的现有证据,同时强调在缺乏随机、安慰剂对照研究的情况下,无法得出这些药物治疗NFPA疗效的最终结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dopamine Agonists in the Management of Non-Functioning Pituitary Adenomas.
Non-functioning pituitary tumors (NFPA) are usually large at the time of diagnosis and present with symptoms caused by compression on the neighbouring structures. Transsphenoidal resection of the tumor is the first-line treatment but in many cases complete tumor resection cannot be attained. Close follow-up with repeated hormonal assessment and pituitary imaging is recommended after surgery. During follow-up of the tumor remnant sometimes radiotherapy is used to stop or prevent tumor progression. Medical treatment with dopamine agonists (DA) is the mainstay in the management of prolactinomas. For NFPA several small series or case reports suggested beneficial effects with tumor shrinkage in some cases. The aim of the current paper is to summarize the available evidence related to the potential efficacy of DA medical treatment in NFPA while underlining that in the absence of randomized, placebo-controlled studies, no final conclusion on the efficacy of these drugs in the treatment of NFPA can be drawn.
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