{"title":"阿尔茨海默病的治疗目标:从苍蝇身上学到的经验","authors":"M. Konsolaki, D. Cohen","doi":"10.1016/S1741-8372(04)02395-3","DOIUrl":null,"url":null,"abstract":"<div><p><span>Neurodegenerative diseases, including </span>Alzheimer's disease (AD), are a major focus of the pharmaceutical industry. Recently, human genetic analyses have aided in the successful identification of a handful of genes responsible for genetically inherited forms of AD, but our understanding of basic mechanisms that lead to the more common sporadic forms of this disease is still limited.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 2","pages":"Pages 64-70"},"PeriodicalIF":0.0000,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02395-3","citationCount":"2","resultStr":"{\"title\":\"Targets for Alzheimer's disease: lessons learnt from flies\",\"authors\":\"M. Konsolaki, D. Cohen\",\"doi\":\"10.1016/S1741-8372(04)02395-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Neurodegenerative diseases, including </span>Alzheimer's disease (AD), are a major focus of the pharmaceutical industry. Recently, human genetic analyses have aided in the successful identification of a handful of genes responsible for genetically inherited forms of AD, but our understanding of basic mechanisms that lead to the more common sporadic forms of this disease is still limited.</p></div>\",\"PeriodicalId\":100382,\"journal\":{\"name\":\"Drug Discovery Today: TARGETS\",\"volume\":\"3 2\",\"pages\":\"Pages 64-70\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02395-3\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today: TARGETS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1741837204023953\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: TARGETS","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1741837204023953","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Targets for Alzheimer's disease: lessons learnt from flies
Neurodegenerative diseases, including Alzheimer's disease (AD), are a major focus of the pharmaceutical industry. Recently, human genetic analyses have aided in the successful identification of a handful of genes responsible for genetically inherited forms of AD, but our understanding of basic mechanisms that lead to the more common sporadic forms of this disease is still limited.