Krushnakumar J. Jilariya, P. K. Patel, Y. Sanghani, Vijay D. Chodvadiya, Jayesh S. Babariya
{"title":"新型(E)-4-(4-((1,3-二苯基- 1h -吡唑-4-基)亚甲基)-氨基)苯基)morpholin-3-one衍生物的合成与表征","authors":"Krushnakumar J. Jilariya, P. K. Patel, Y. Sanghani, Vijay D. Chodvadiya, Jayesh S. Babariya","doi":"10.14233/ajomc.2019.ajomc-p224","DOIUrl":null,"url":null,"abstract":"A highly functionalized heterocyclic compounds series were synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel synthetic route involves Schiff base formation reaction of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. All the synthesized compounds were characterized using IR, 1H NMR and mass spectroscopic techniques. All the compound screened for antimicrobial activity against standard drugs.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"98 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Characterization of Novel (E)-4-(4-(((1,3-diphenyl-1H-pyrazol-4-yl)methylene)-\\namino)phenyl)morpholin-3-one Derivatives\",\"authors\":\"Krushnakumar J. Jilariya, P. K. Patel, Y. Sanghani, Vijay D. Chodvadiya, Jayesh S. Babariya\",\"doi\":\"10.14233/ajomc.2019.ajomc-p224\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A highly functionalized heterocyclic compounds series were synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel synthetic route involves Schiff base formation reaction of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. All the synthesized compounds were characterized using IR, 1H NMR and mass spectroscopic techniques. All the compound screened for antimicrobial activity against standard drugs.\",\"PeriodicalId\":8846,\"journal\":{\"name\":\"Asian Journal of Organic & Medicinal Chemistry\",\"volume\":\"98 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Organic & Medicinal Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14233/ajomc.2019.ajomc-p224\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic & Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14233/ajomc.2019.ajomc-p224","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and Characterization of Novel (E)-4-(4-(((1,3-diphenyl-1H-pyrazol-4-yl)methylene)-
amino)phenyl)morpholin-3-one Derivatives
A highly functionalized heterocyclic compounds series were synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel synthetic route involves Schiff base formation reaction of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. All the synthesized compounds were characterized using IR, 1H NMR and mass spectroscopic techniques. All the compound screened for antimicrobial activity against standard drugs.