Pooneh Allahyari, Mina Ahmadzadeh, Farhad Vahid, Maryam Gholamalizadeh, Hanieh Shafaei, Soheila Shekari, Naeemeh Hasanpour Ardekanizadeh, Fatemeh Shafiee, Nazanin Majidi, Mohammad Esmail Akbari, Saeid Doaei, Mark O Goodarzi
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The control group had a significantly higher intake of vitamin D (1.79±1.56 vs. 1.05±0.84 μg/d; P=0.01) and lower intake of calorie (2315±1066 vs. 2737±925 kcal/d; P=0.01), carbohydrate (311±170 vs. 402±124 g/d; P=0.01), iron (15.4±12.1 vs. 19.7±6.4 mg/d; P=0.01), thiamine (1.5±0.7 vs. 2.3±0.9 mg/d; P=0.01), niacin (18.2±9.2 vs. 24.3±7.9 mg/d; P=0.01), folic acid (465±308.7 vs. 673±205.2 μg/d; P=0.01), and selenium (82.6±41.7 vs. 98.7±40.8 μg/d; P=0.01) compared to the case group. No significant association was found between DAI with breast cancer after adjustments for age. DAI had a negative association with breast cancer after additional adjustments for BMI, the number of pregnancies, duration of breastfeeding, menopause age, and total energy intake (OR: 0.91, 95% CI: 0.90-.93, and all P<0.001). The present study identified a negative association between DAI and the risk of BC, indicating the importance of antioxidants in preventing BC. 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引用次数: 1
摘要
最近有研究报告称,膳食抗氧化剂可影响乳腺癌(BC)的发病风险。因此,本研究旨在调查伊朗妇女的膳食抗氧化指数(DAI)与乳腺癌之间的关系。这项病例对照研究的对象是在伊朗德黑兰 Shohadaye Tajrish 医院癌症诊所就诊的 180 名乳腺癌妇女和 360 名健康妇女。研究采用了 168 项有效食物频率问卷 (FFQ) 来评估饮食摄入量。根据 FFQ 得出的抗氧化维生素和矿物质摄入量计算 DAI 分数。对照组的维生素 D 摄入量明显较高(1.79±1.56 vs. 1.05±0.84 μg/d;P=0.01),而热量(2315±1066 vs. 2737±925 kcal/d;P=0.01)、碳水化合物(311±170 vs. 402±124 g/d;P=0.01)、铁(15.4±12.1 vs. 19.7±6.4 mg/d; P=0.01)、硫胺素(1.5±0.7 vs. 2.3±0.9 mg/d; P=0.01)、烟酸(18.2±9.2 vs. 24.3±7.9 mg/d; P=0.01)、叶酸(465±308.7 vs. 673±205.2 μg/d;P=0.01)和硒(82.6±41.7 vs. 98.7±40.8 μg/d;P=0.01)。在对年龄进行调整后,未发现 DAI 与乳腺癌之间存在明显关联。在对体重指数、怀孕次数、母乳喂养时间、绝经年龄和总能量摄入进行额外调整后,DAI 与乳腺癌呈负相关(OR:0.91,95% CI:0.90-.93,P=0.01)。
The association of dietary antioxidant index (DAI) with breast cancer among Iranian women.
Recent studies have reported that dietary antioxidants can influence the risk of breast cancer (BC). Therefore, this study aimed to investigate the association of dietary antioxidant index (DAI) with BC among Iranian women. This case-control study was conducted on 180 women with breast cancer and 360 healthy women who were referred to the cancer clinic of Shohadaye Tajrish Hospital in Tehran, Iran. A 168-item validated food frequency questionnaire (FFQ) was used to assess dietary intake. The DAI score was calculated based on the intake of antioxidant vitamins and minerals derived from the FFQ. The control group had a significantly higher intake of vitamin D (1.79±1.56 vs. 1.05±0.84 μg/d; P=0.01) and lower intake of calorie (2315±1066 vs. 2737±925 kcal/d; P=0.01), carbohydrate (311±170 vs. 402±124 g/d; P=0.01), iron (15.4±12.1 vs. 19.7±6.4 mg/d; P=0.01), thiamine (1.5±0.7 vs. 2.3±0.9 mg/d; P=0.01), niacin (18.2±9.2 vs. 24.3±7.9 mg/d; P=0.01), folic acid (465±308.7 vs. 673±205.2 μg/d; P=0.01), and selenium (82.6±41.7 vs. 98.7±40.8 μg/d; P=0.01) compared to the case group. No significant association was found between DAI with breast cancer after adjustments for age. DAI had a negative association with breast cancer after additional adjustments for BMI, the number of pregnancies, duration of breastfeeding, menopause age, and total energy intake (OR: 0.91, 95% CI: 0.90-.93, and all P<0.001). The present study identified a negative association between DAI and the risk of BC, indicating the importance of antioxidants in preventing BC. Longitudinal studies should be conducted to confirm this association.
期刊介绍:
Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds.
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