异丙酚在正常人大脑中的作用部位的功能磁共振成像研究

Hui Zhang, Wei Wang, Zhijing Zhao, Y. Ge, Jinsong Zhang, Daihua Yu, W. Chai, Shengxi Wu, Lixian Xu
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引用次数: 4

摘要

异丙酚已使用多年,但其在完整大脑中的功能靶点仍不清楚。本研究采用功能磁共振成像技术,观察异丙酚麻醉过程中正常人大脑血氧水平依赖性信号的变化,探讨异丙酚可能的作用靶点。10名健康受试者参加了两个实验阶段。在第1阶段,采用观察者警觉/镇静量表评估睡眠到清醒/警觉状态。在第二阶段,在1.5 - T Philips Gyroscan磁共振系统上通过回波平面成像获得了血氧水平依赖性对比图像并进行了分析。在两个疗程中,受试者均静脉注射生理盐水(3分钟),然后在恒速输液泵下再次注射异丙酚(1.5分钟)和生理盐水(10.5分钟)。观察者警觉性/镇静量表评分显示受试者经历了意识-镇静-无意识-睡眠,这与麻醉状态下的信号减少有很好的相关性。异丙酚引起下丘脑(18.2%±3.6%)、额叶(68.5%±11.2%)、颞叶(34.7%±6.1%)信号明显下降。此外,这三个位点的信号是暴发性的,并且是同步变化的。而在丘脑,10名受试者中有5名出现信号减弱,幅度为3.9%±1.6%。这些结果表明,异丙酚麻醉对下丘脑、额叶和颞叶的抑制作用最为显著,对丘脑的抑制作用为中度。这些脑区可能是异丙酚麻醉在人脑中的作用靶点。Anat Rec, 2010。©2010 Wiley‐Liss, Inc。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Action Sites of Propofol in the Normal Human Brain Revealed by Functional Magnetic Resonance Imaging
Propofol has been used for many years but its functional target in the intact brain remains unclear. In the present study, we used functional magnetic resonance imaging to demonstrate blood oxygen level dependence signal changes in the normal human brain during propofol anesthesia and explored the possible action targets of propofol. Ten healthy subjects were enrolled in two experimental sessions. In session 1, the Observer's Assessment of Alertness/Sedation Scale was performed to evaluate asleep to awake/alert status. In session 2, images with blood oxygen level dependence contrast were obtained with echo‐planar imaging on a 1.5‐T Philips Gyroscan Magnetic Resonance System and analyzed. In both sessions, subjects were intravenously administered with saline (for 3 min) and then propofol (for 1.5 min) and saline again (for 10.5 min) with a constant speed infusion pump. Observer's Assessment of Alertness/Sedation Scale scoring showed that the subjects experienced conscious–sedative–unconscious–analepsia, which correlated well with the signal decreases in the anesthesia states. Propofol induced significant signal decreases in hypothalamus (18.2% ± 3.6%), frontal lobe (68.5% ± 11.2%), and temporal lobe (34.7% ± 6.1%). Additionally, the signals at these three sites were fulminant and changed synchronously. While in the thalamus, the signal decrease was observed in 5 of 10 of the subjects and the magnitude of decrease was 3.9% ± 1.6%. These results suggest that there is most significant inhibition in hypothalamus, frontal lobe, and temporal in propofol anesthesia and moderate inhibition in thalamus. These brain regions might be the targets of propofol anesthesia in human brain. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
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