BMP signaling-related proteins are differentially expressed in the adult cerebellum

We investigated the distributions of BMP ligands (BMP2, BMP4, BMP5), BMP receptors (BMPR) (BMPRIA, BMPR IB, BMPR II ), BMP antagonists (chordin and noggin) in the adult rat cerebellum. plastic phenomena, such as long-term depression (LTD) and rebound potentiation (RP) are observed, than in the granule cell layer. In addition, neurons in the cerebellar nuclei also express all of them. We also found differential usages of BMPRIA and BMPRIB in the cerebellum. For example, in the molecular layer, BMPRIA is mainly expressed in the processes of Bergmann glia, while BMPRIB is mainly detected in the dendrites of Purkinje cells. In addition, BMPRIB is expressed in both cell bodies and dendrites of Purkinje cells, while BMPRIA is mainly expressed in cell bodies of Purkinje cells, showing that BMPRIA and BMPRIB are differentially targeted in a Purkinje cell. These data strongly indicate that differential BMP signaling should be needed to keep the proper function of the cerebellum in the adult rat cerebellum.