APOL1 基因变异与白人肾病:心血管健康研究。

IF 2.2 4区 教育学 Q1 Social Sciences
Erika R Drury, David J Friedman, Martin R Pollak, Joachim H Ix, Lewis H Kuller, Russell P Tracy, Kenneth J Mukamal
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引用次数: 0

摘要

APOL1基因的两个编码变异使非裔美国人患非糖尿病肾病的风险显著增加[1]。这些变异分别存在于约23%和14%的非裔美国人染色体中,包括被称为G1的两组氨基酸替换和被称为G2的6个碱基对缺失,而在那些没有近期非洲血统的人中则不存在[2]。最近的报道描述了这些APOL1肾脏风险变异与心血管疾病之间的关联,但结果不一致[3]。大量编码,染色体和包涵14和没有超出G1和G2的变型为节段性肾小球硬化,APOL1未知,与亚临床程度的肾功能障碍有关,在最近没有非洲项目检查APOL1变异和肾脏和心血管疾病风险的个体中,be或其他潜在表型。为了解决这些问题,我们测试了一组候选单核苷酸多态性之间的关联
本文章由计算机程序翻译,如有差异,请以英文原文为准。
APOL1 gene variants and kidney disease in whites: the cardiovascular health study.
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来源期刊
CiteScore
6.70
自引率
0.00%
发文量
25
期刊介绍: The Journal of Experimental Education publishes theoretical, laboratory, and classroom research studies that use the range of quantitative and qualitative methodologies. Recent articles have explored the correlation between test preparation and performance, enhancing students" self-efficacy, the effects of peer collaboration among students, and arguments about statistical significance and effect size reporting. In recent issues, JXE has published examinations of statistical methodologies and editorial practices used in several educational research journals.
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