Muscle-kidney crosstalk; the role of myokines

Muscle-kidney crosstalk refers to the communication and interaction between skeletal muscle tissue and the kidneys. One important aspect of this crosstalk is the role of myokines. Myokines are a class of bioactive molecules that are released by contracting skeletal muscles. They act as signaling molecules that can mediate communication between muscle tissue and various target organs, including the kidneys. Myokines are involved in regulating various physiological processes and have been shown to have both local and systemic effects.