{"title":"抗链霉亲和素抗体对甲状旁腺激素测定的干扰病例报告","authors":"B. Trautz, T. Negele","doi":"10.34172/jpd.2022.6134","DOIUrl":null,"url":null,"abstract":"Endogenous antibodies can lead to test interference in streptavidin-biotin based laboratory assays, such as thyroid function tests or parathyroid hormone (PTH) levels. We report about a patient, who presented for thyroid surgery, showing undetectable PTH levels despite normocalcaemia in internally assessed preoperative laboratory work. Previously, anti-streptavidin antibodies were detected in the patient’s blood and normal PTH levels could be measured in a streptavidin-free assay. To our knowledge this is the first reported case of a clinically relevant PTH test interference due to endogenous anti-streptavidin antibodies, thus complicating the evaluation of postoperative hypoparathyroidism.","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interference caused by anti-streptavidin antibodies in a parathyroid hormone assay; a case report\",\"authors\":\"B. Trautz, T. Negele\",\"doi\":\"10.34172/jpd.2022.6134\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Endogenous antibodies can lead to test interference in streptavidin-biotin based laboratory assays, such as thyroid function tests or parathyroid hormone (PTH) levels. We report about a patient, who presented for thyroid surgery, showing undetectable PTH levels despite normocalcaemia in internally assessed preoperative laboratory work. Previously, anti-streptavidin antibodies were detected in the patient’s blood and normal PTH levels could be measured in a streptavidin-free assay. To our knowledge this is the first reported case of a clinically relevant PTH test interference due to endogenous anti-streptavidin antibodies, thus complicating the evaluation of postoperative hypoparathyroidism.\",\"PeriodicalId\":16657,\"journal\":{\"name\":\"Journal of Parathyroid Disease\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Parathyroid Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/jpd.2022.6134\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Parathyroid Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/jpd.2022.6134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Interference caused by anti-streptavidin antibodies in a parathyroid hormone assay; a case report
Endogenous antibodies can lead to test interference in streptavidin-biotin based laboratory assays, such as thyroid function tests or parathyroid hormone (PTH) levels. We report about a patient, who presented for thyroid surgery, showing undetectable PTH levels despite normocalcaemia in internally assessed preoperative laboratory work. Previously, anti-streptavidin antibodies were detected in the patient’s blood and normal PTH levels could be measured in a streptavidin-free assay. To our knowledge this is the first reported case of a clinically relevant PTH test interference due to endogenous anti-streptavidin antibodies, thus complicating the evaluation of postoperative hypoparathyroidism.
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