1例急性病毒性心肌炎患者临床过程中Th1/Th2平衡的改变

K. Fuse, M. Kodama, Y. Aizawa, M. Yamaura, Y. Tanabe, K. Takahashi, K. Sakai, T. Miida, H. Oda, N. Higuma
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引用次数: 22

摘要

细胞因子在心肌炎的发病机制和病理生理中起着重要作用。本研究采用三色流式细胞术对急性病毒性心肌炎患者外周血辅助性T淋巴细胞(Th)亚群进行了分析。在心肌炎的临床病程中,外周血淋巴细胞Th1/Th2比值发生变化。在急性炎症期,肌酸激酶(CK)水平升高(第6天),Th1占主导地位;在恢复期,肌酸激酶(CK)水平下降(第13天和第20天),Th2水平超过Th1。出院时(第35天),Th1和Th2恢复正常。由此推测,淋巴细胞性心肌炎的诱发与Th1显性有关,恢复与Th2极性有关。亚群失衡可能在急性病毒性心肌炎的发病机制中起重要作用,这些分析可能有助于了解心肌炎的疾病活动性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Th1/Th2 balance alteration in the clinical course of a patient with acute viral myocarditis.
Cytokines have an important role in the pathogenesis and pathophysiology of myocarditis. In this study, subsets of peripheral helper T lymphocytes (Th) in a patient with acute viral myocarditis were analyzed by 3-color flow cytometry. During the clinical course of myocarditis, the Th1/Th2 ratio of peripheral lymphocytes changed. Th1 was dominant in the acute inflammatory phase during which levels of creatine kinase (CK) increased (day 6), then Th2 levels overtook those of Th1 in the recovery phase during which levels of CK decreased (day 13 and 20). At the time of discharge (day 35), Th1 and Th2 had normalized. Thus, it was speculated that the induction of lymphocytic myocarditis was associated with Th1 dominant status, and recovery was related to Th2 polarity. Th subset imbalances may play an important role in the pathogenesis of acute viral myocarditis and these analyses may be useful for understanding the disease activity of myocarditis.
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