吉尔吉斯共和国人口代表性样本中的心肌肌钙蛋白I:分布、种族差异和与危险因素的关联

Q4 Medicine

Arterial Hypertension (Russian Federation) Pub Date : 2023-01-17 DOI:10.18705/1607-419x-2022-28-6-79-90

А. V. Kontsevaya, A. Polupanov, D. Mukaneeva, V. Kutsenko, E. Yarovaya, M. T. Duishenalieva, A. V. Belinova, Zh.A. Mamasaidov, O. Drapkina

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The analysis of cTnI levels in the population and associations of cTnI levels with socio-demographic parameters (sex, age, education, etc.), risk factors (smoking, obesity, hypertension, etc.), blood biochemical parameters (triglycerides, lipid profile, glucose) and an anamnesis of cardiovascular diseases and total cardiovascular risk according to the SCORE scale. The statistical significance level was considered equal to 0,05. Results. The median cTnI level in the Kyrgyz sample was 0,90 pg/ml [0,40; 1,80]. The 99th percentile for the entire sample was 21,4 pg/ml in men and 12,2 pg/ml in women. The median cTnI in the Slavs sample was 1,40 pg/ml [0,60; 2,20]. The 99th percentile for the entire sample was 21,2 pg/ml in men and 25,2 pg/ml in women. The cTnI level log increases significantly with age in both men and women. At the age of 20-30 years, the cTnI level in men is higher than in women in both ethnic groups. 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引用次数: 0

摘要

目标。评估心肌肌钙蛋白I (cTnI)在吉尔吉斯共和国人群样本中的分布，研究其与危险因素的关系，并确定可能的种族差异。设计和方法。本观察性横断面研究包括吉尔吉斯共和国20-64岁人口的代表性样本(n = 1256)。人群中cTnI水平的分析，以及cTnI水平与社会人口学参数(性别、年龄、教育程度等)、危险因素(吸烟、肥胖、高血压等)、血液生化参数(甘油三酯、血脂、葡萄糖)、心血管疾病的记忆和根据SCORE量表的心血管总风险之间的关系。认为统计学显著性水平为0.05。结果。吉尔吉斯样本的中位cTnI水平为0,90 pg/ml [0,40;1, 80]。整个样本的第99百分位男性为21.4 pg/ml，女性为12.2 pg/ml。Slavs样本的中位cTnI为1,40 pg/ml [0,60;2, 20)。整个样本的第99百分位男性为21.2 pg/ml，女性为25.2 pg/ml。在男性和女性中，cTnI水平随年龄的增长而显著增加。在20-30岁时，两族男性的cTnI水平均高于女性。然而，随着年龄的增长，在两个民族中，女性cTnI的增长率都高于男性。在一项多变量分析中，cTnI水平与性别、年龄、高血压、中风、血液中总胆固醇和甘油三酯水平显著相关。通过SCORE风险对研究参与者进行分类的准确性不足。结论。cTnI是一种潜在的强大生物标志物，补充了传统的风险量表，适用于心血管疾病一级预防策略的框架，这在吉尔吉斯共和国人口的研究中得到了证实。

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Cardiac troponin I in a representative sample of the Kyrgyz Republic population: distribution, ethnic differences, and association with risk factors

Objective. To assess the distribution of cardiac troponin I (cTnI) in a sample of the Kyrgyz Republic population, to study its associations with risk factors and to identify the possible ethnic differences. Design and methods. This observational cross-sectional study includes a representative sample of the Kyrgyz Republic population aged 20–64 years (n = 1256). The analysis of cTnI levels in the population and associations of cTnI levels with socio-demographic parameters (sex, age, education, etc.), risk factors (smoking, obesity, hypertension, etc.), blood biochemical parameters (triglycerides, lipid profile, glucose) and an anamnesis of cardiovascular diseases and total cardiovascular risk according to the SCORE scale. The statistical significance level was considered equal to 0,05. Results. The median cTnI level in the Kyrgyz sample was 0,90 pg/ml [0,40; 1,80]. The 99th percentile for the entire sample was 21,4 pg/ml in men and 12,2 pg/ml in women. The median cTnI in the Slavs sample was 1,40 pg/ml [0,60; 2,20]. The 99th percentile for the entire sample was 21,2 pg/ml in men and 25,2 pg/ml in women. The cTnI level log increases significantly with age in both men and women. At the age of 20-30 years, the cTnI level in men is higher than in women in both ethnic groups. However, with age, the increase rate of cTnI in women is higher than in men in both ethnic groups. In a multivariate analysis, significant associations of cTnI levels with sex, age, hypertension, stroke, blood levels of total cholesterol and triglycerides were obtained. Insufficient accuracy of classification of study participants by SCORE risk was revealed. Conclusions. cTnI is a potential strong biomarker that complements traditional risk scales and is applicable in the framework of cardiovascular diseases primary prevention strategies, which was confirmed in this study on the Kyrgyz Republic population.

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来源期刊

Arterial Hypertension (Russian Federation) Medicine-Cardiology and Cardiovascular Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication. The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.