Promoter Hypermethylation of Apoptotic genes in Oral Squamous Cell Carcinoma

Cancer stands among the foremost advanced human diseases with multiple levels of regulation. Despite the numerous progress that has been created in basic and clinical analysis, the incidence associated mortality rates related to malignant pathologies are still at high levels with an expected raised rate within the next fifteen years Irimie et al. [1]. The sixth most typical malignancy that has been found is Head and Neck cancer, wherever carcinoma represents the foremost frequent subtype inside this spectrum Irimie et al. [2], Hema et al. [3]. Also, Oral Squamous Cell Carcinoma (OSCC) accounts for roughly ninetieth of the oral subtype, being far and away the foremost common sort of malignancy inside the mouth Parkin et al. [4], Stewart et al. [5]. Apoptosis is that one pathway that could lead the elimination of oncogenic cells. Apoptosis can be explained as a process in which natural death of cells is initiated to maintain the cellular homeostasis. A variety of changes are done in the structure of cells by apoptotic proteins that eliminate the cell out of body. In this mechanism events occurs which result into formation of cascades that encounters the already anteceding cells leading them to demise, also known as “programmed cell death”, Elmore [6], Hervouet et al. [7]. The initiation and maturation of oral carcinoma caused by total of genetic changes combined with environmental risk factors (special mention to alcohol and tobacco use however various viral infectious agents and persistent inflammations) cause changes within the pursuit of cancer causing genes i.e., oncogenes and tumour suppressor genes Perez et al. [8], Irimie et al. [9].