Takashi Shimada , Yunqing Cai , Lei Cheng , Chie Motonaga , Kazutake Fukada , Yoshihisa Kitamura , Jieshu Wu
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Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice
Objective
The purpose of this study was to evaluate the effects of Enterococcus faecalis FK-23(FK-23) on the immune function in mice.
Methods
Mice were treated with three doses of the FK-23(0.05, 0.1, 0.2, 0.6 g/kg body weight) for 30 days. Delayed type hypersensitivity (DTH), monocyte phagocytic function, serum hemolysis antibody and natural killer cell activity were studied.
Results
The significant increases in mice treated with 0.6 g/kg bw were found in DTH, phagocytic function of monocyte, serum hemolysis antibody and natural killer cell activity.
Conclusion
The results from the present study suggest that FK-23 could improve both specific and non-specific immune function.
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