双滤浆分离洗脱液中的颗粒——场发射扫描电镜/能量色散x射线能谱(FE-SEM/EDX)研究

Compounds Pub Date : 2022-12-01 DOI:10.3390/compounds2040030
F. Scholkmann, A. Gatti
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引用次数: 0

摘要

使用双过滤血浆置换(DFPP)可以有效地从血液中去除不需要的物质。在我们的案例研究中,我们使用场发射扫描电子显微镜/能量色散x射线分析(FE-SEM-EDX)来检查由特定类型的DFPP(带有TKM58过滤器的INUSpheresis)获得的洗脱液是否含有纳米和微颗粒以及这些颗粒的化学成分。我们发现了各种大小和化学成分的微粒子和纳米粒子,包括钙、铁、硅、铝和钛含量很高的微粒子。此外,还发现了线状物体。我们讨论了这些颗粒和物体的可能来源,它们的病理生理相关性,以及FE-SEM-EDX分析在诊断和治疗患者环境医学应用方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Particles in the Eluate from Double Filtration Plasmapheresis—A Case Study Using Field Emission Scanning Electron Microscopy/Energy-Dispersive X-ray Spectroscopy (FE-SEM/EDX)
Unwanted substances can be effectively removed from the blood using double-filtration plasmapheresis (DFPP). In our case study, we used field emission scanning electron microscopy/energy-dispersive X-ray analysis (FE-SEM-EDX) to examine if the eluate obtained by a specific type of DFPP (INUSpheresis with a TKM58 filter) contains nano- and microparticles and what chemical composition these particles have. We identified micro- and nanoparticles of various sizes and chemical composition, including microparticles high in the concentration of calcium, iron, silicon, aluminium and titanium. Furthermore, thread-like objects were identified. We discuss the possible origin of the particles and objects, their pathophysiological relevance and the potential of FE-SEM-EDX analysis of the eluate in terms of diagnostics and therapy for environmental medicine applications on patients.
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CiteScore
2.30
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