Nadia Abdalhafid Elsherif , Abdalla I. El-Sherif , Salwa A. El-Dibany
{"title":"皮肤疾病血清催乳素水平:一项病例对照研究","authors":"Nadia Abdalhafid Elsherif , Abdalla I. El-Sherif , Salwa A. El-Dibany","doi":"10.1016/j.jdds.2015.03.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Recent lines of evidence suggest that prolactin (PRL) as a neurohormone may play a role in the activity of psoriasis and some other immune-mediated diseases. Our aim was to evaluate the correlation between serum PRL levels and severity of psoriasis, vitiligo and alopecia areata.</p></div><div><h3>Patients and methods</h3><p>We performed a case–control study on 100 subjects: 75 patients; suffering from psoriasis, vitiligo and alopecia areata; 25 patients in each group and 25 age- and sex-matched healthy controls.</p></div><div><h3>Results</h3><p>Serum prolactin levels were significantly high in all three dermatological diseases in comparison with the control group (<em>P</em> <!-->=<!--> <!-->0.000). The mean<!--> <!-->±<!--> <!-->SD of the serum prolactin levels was 21.8<!--> <!-->±<!--> <!-->11.5<!--> <!-->ng/ml, 16.9<!--> <!-->±<!--> <!-->6.8<!--> <!-->ng/ml, and 16.6<!--> <!-->±<!--> <!-->8.0<!--> <!-->ng/ml in patients with alopecia areata, psoriasis and vitiligo respectively. Moreover, the serum prolactin levels in patients with alopecia areata and psoriasis were significantly correlated with disease severity (<em>P</em> <!--><<!--> <!-->0.05), however no statistically significant correlation was noted between vitiligo severity and serum prolactin levels (<em>P</em> <!-->><!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>Prolactin may play a role in the pathogenesis of alopecia areata, psoriasis, and vitiligo; and may serve as a biological marker of disease activity in patients with psoriasis and alopecia areata.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 2","pages":"Pages 104-107"},"PeriodicalIF":0.2000,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2015.03.002","citationCount":"4","resultStr":"{\"title\":\"Serum prolactin levels in dermatological diseases: A case–control study\",\"authors\":\"Nadia Abdalhafid Elsherif , Abdalla I. El-Sherif , Salwa A. El-Dibany\",\"doi\":\"10.1016/j.jdds.2015.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Recent lines of evidence suggest that prolactin (PRL) as a neurohormone may play a role in the activity of psoriasis and some other immune-mediated diseases. Our aim was to evaluate the correlation between serum PRL levels and severity of psoriasis, vitiligo and alopecia areata.</p></div><div><h3>Patients and methods</h3><p>We performed a case–control study on 100 subjects: 75 patients; suffering from psoriasis, vitiligo and alopecia areata; 25 patients in each group and 25 age- and sex-matched healthy controls.</p></div><div><h3>Results</h3><p>Serum prolactin levels were significantly high in all three dermatological diseases in comparison with the control group (<em>P</em> <!-->=<!--> <!-->0.000). The mean<!--> <!-->±<!--> <!-->SD of the serum prolactin levels was 21.8<!--> <!-->±<!--> <!-->11.5<!--> <!-->ng/ml, 16.9<!--> <!-->±<!--> <!-->6.8<!--> <!-->ng/ml, and 16.6<!--> <!-->±<!--> <!-->8.0<!--> <!-->ng/ml in patients with alopecia areata, psoriasis and vitiligo respectively. Moreover, the serum prolactin levels in patients with alopecia areata and psoriasis were significantly correlated with disease severity (<em>P</em> <!--><<!--> <!-->0.05), however no statistically significant correlation was noted between vitiligo severity and serum prolactin levels (<em>P</em> <!-->><!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>Prolactin may play a role in the pathogenesis of alopecia areata, psoriasis, and vitiligo; and may serve as a biological marker of disease activity in patients with psoriasis and alopecia areata.</p></div>\",\"PeriodicalId\":43409,\"journal\":{\"name\":\"Journal of Dermatology & Dermatologic Surgery-JDDS\",\"volume\":\"19 2\",\"pages\":\"Pages 104-107\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2015-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jdds.2015.03.002\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Dermatology & Dermatologic Surgery-JDDS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352241015000237\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dermatology & Dermatologic Surgery-JDDS","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352241015000237","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Serum prolactin levels in dermatological diseases: A case–control study
Background
Recent lines of evidence suggest that prolactin (PRL) as a neurohormone may play a role in the activity of psoriasis and some other immune-mediated diseases. Our aim was to evaluate the correlation between serum PRL levels and severity of psoriasis, vitiligo and alopecia areata.
Patients and methods
We performed a case–control study on 100 subjects: 75 patients; suffering from psoriasis, vitiligo and alopecia areata; 25 patients in each group and 25 age- and sex-matched healthy controls.
Results
Serum prolactin levels were significantly high in all three dermatological diseases in comparison with the control group (P = 0.000). The mean ± SD of the serum prolactin levels was 21.8 ± 11.5 ng/ml, 16.9 ± 6.8 ng/ml, and 16.6 ± 8.0 ng/ml in patients with alopecia areata, psoriasis and vitiligo respectively. Moreover, the serum prolactin levels in patients with alopecia areata and psoriasis were significantly correlated with disease severity (P < 0.05), however no statistically significant correlation was noted between vitiligo severity and serum prolactin levels (P > 0.05).
Conclusions
Prolactin may play a role in the pathogenesis of alopecia areata, psoriasis, and vitiligo; and may serve as a biological marker of disease activity in patients with psoriasis and alopecia areata.
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