Zn(II)/Cu(II)配合物与2,2 ' -二苯基乙酸/2-(4-羟基苯基)乙酸前体及氮基的合成、表征及DNA结合研究

Muhammad Naeem, Saqib Ali, S. Shahzadi, K. Ullah, S. Hussain, S. Ramzan, S. Kamal
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引用次数: 0

摘要

通式(RCOO)2M的水合配合物1、3、7、8。xH2O(其中M = Zn & x = 6;M = Cu和x = 5,6)分别由2,2 ' -二苯基乙酸钠盐和2-(4-羟基苯基)乙酸(RCOONa)与Zn(NO3)2.6H2O或CuSO4.5H2O在水溶液中反应合成。将联吡啶(bpy)或1,10-菲罗啉(phen)的甲醇溶液加入到原位生产的1,3,7和8的水悬浮液中,可形成通式(RCOO)2M(bpy)的混合配体产物。xH2O(2,4,9和10)和(RCOO)2M(phen)。配合物通过微量分析、FTIR和NMR (1H和13C)光谱技术进行了表征。FTIR数据表明羧酸配体具有双齿配位模式,配合物在固体状态下具有四/六配位的几何结构。光谱数据还显示所有配合物中都存在配位水分子。1H和13C核磁共振数据证实了配合物1中配体与金属之间的配位。测试了这些复合物与鲑鱼精子DNA (SS-DNA)的结合。配合物的DNA结合电位归因于金属锌的存在和结合配体的性质。该配合物表现出明显的异色效应和与SS-DNA的嵌入结合模式。对这些复合物进行了抗多种细菌和真菌的生物活性筛选。所有复合物均表现出明显的抑菌活性,但均未表现出抑菌活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis, Characterization and DNA Binding Studies of Zn(II)/Cu(II) Complexes with 2,2`-Diphenyl Acetic Acid/2-(4-Hydroxyphenyl)Acetic Acid Ligand Precursors and Nitrogen Bases
The hydrated complexes 1, 3, 7 and 8 with the general formula (RCOO)2M.xH2O (where M = Zn & x = 6; M = Cu & x = 5,6) were synthesized by the reaction of sodium salt of 2,2`-diphenyl acetic acid or 2-(4-hydroxyphenyl)acetic acid (RCOONa) with Zn(NO3)2.6H2O or CuSO4.5H2O in an aqueous medium. The addition of methanolic solution of either bipyridine (bpy) or 1,10-phenanthroline (phen) to an aqueous suspension of 1, 3, 7 and 8 (produced in situ) result in the formation of mixed ligand products with the general formulae (RCOO)2M(bpy).xH2O (2, 4, 9 and 10) and (RCOO)2M(phen).xH2O (5 and 6). The complexes were characterized by microanalysis, FTIR and NMR (1H and 13C) spectroscopic techniques. The FTIR data suggested a bidentate coordination mode of the carboxylate ligand and complexes exhibited four/six-coordinated geometry in the solid state. The spectroscopic data also revealed the presence of coordinated water molecules in all complexes. 1H and 13C NMR data demonstrated the coordination between ligand and the metal in complex 1. The complexes were tested for their binding with salmon sperm DNA (SS-DNA). The DNA binding potential of the complexes owed to the presence of zinc metal and the nature of the incorporated ligand. The complexes showed a significant hypochromic effect and an intercalating mode of binding with SS-DNA. The complexes were screened against various bacterial and fungal strains to check their biological activity. All the complexes showed significant antibacterial activity but none of complex exhibit antifungal activity.
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