{"title":"重组干扰素- α 2b治疗眼表鳞瘤(OSSN)","authors":"Kadir Smu","doi":"10.23880/oajo-16000218","DOIUrl":null,"url":null,"abstract":"Ocular surface squamous neoplasia (OSSN) is an ambit of ocular surface diseases encompassing dysplasia to different grades of invasive squamous cell carcinoma of the ocular surface. The typical presentation is the leukoplakic appearance with feeder vessels of conjunctiva, limbus, and cornea. Histological confirmation after incisional/excisional biopsy has been considered the gold standard for OSSN. 5-fluorouracil (5-FU) and mitomycin C (MMC) has used as adjuvant topical chemotherapy. Recently, interferon-alpha 2b (INF α2b) is operating as immunotherapy for the treatment of OSSN. Good outcome with fewer side effects than other drugs are reported. An overview on INF α2b for the treatment of OSSN is attempting to analyze mode of action, dose and duration, and treatment modality and outcome of INF α2b.","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recombinant Interferon-Alpha 2b for Ocular Surface Squamous Neoplasia (OSSN)\",\"authors\":\"Kadir Smu\",\"doi\":\"10.23880/oajo-16000218\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ocular surface squamous neoplasia (OSSN) is an ambit of ocular surface diseases encompassing dysplasia to different grades of invasive squamous cell carcinoma of the ocular surface. The typical presentation is the leukoplakic appearance with feeder vessels of conjunctiva, limbus, and cornea. Histological confirmation after incisional/excisional biopsy has been considered the gold standard for OSSN. 5-fluorouracil (5-FU) and mitomycin C (MMC) has used as adjuvant topical chemotherapy. Recently, interferon-alpha 2b (INF α2b) is operating as immunotherapy for the treatment of OSSN. Good outcome with fewer side effects than other drugs are reported. An overview on INF α2b for the treatment of OSSN is attempting to analyze mode of action, dose and duration, and treatment modality and outcome of INF α2b.\",\"PeriodicalId\":91939,\"journal\":{\"name\":\"Open access journal of ophthalmology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open access journal of ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23880/oajo-16000218\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open access journal of ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23880/oajo-16000218","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Recombinant Interferon-Alpha 2b for Ocular Surface Squamous Neoplasia (OSSN)
Ocular surface squamous neoplasia (OSSN) is an ambit of ocular surface diseases encompassing dysplasia to different grades of invasive squamous cell carcinoma of the ocular surface. The typical presentation is the leukoplakic appearance with feeder vessels of conjunctiva, limbus, and cornea. Histological confirmation after incisional/excisional biopsy has been considered the gold standard for OSSN. 5-fluorouracil (5-FU) and mitomycin C (MMC) has used as adjuvant topical chemotherapy. Recently, interferon-alpha 2b (INF α2b) is operating as immunotherapy for the treatment of OSSN. Good outcome with fewer side effects than other drugs are reported. An overview on INF α2b for the treatment of OSSN is attempting to analyze mode of action, dose and duration, and treatment modality and outcome of INF α2b.
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