肺栓塞死亡率的预测因素:一项现实生活研究

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL
Fusun Fakili, M. Taylan, İrem Zehra Bilgiç, İ. Düzen
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引用次数: 0

摘要

目的:本研究的主要目的是探讨肺栓塞患者的死亡率及其相关因素。方法:回顾性分析2017年1月1日至2023年1月1日在X大学医院就诊的肺栓塞成年患者。测定肺栓塞患者的全因死亡率及相关因素。结果:本研究纳入152例患者,中位年龄59岁,女性81例(53.3%)。全因死亡率为25.7%,肺栓塞相关死亡率为1.3%。年龄(p<0.001)、慢性阻塞性肺疾病(COPD) (p=0.013)、心力衰竭(p=0.018)、心房颤动(p=0.015)、大量肺栓塞(p=0.029)、血红蛋白水平(p<0.001)和NT-Pro BNP水平(p<0.001)与全因死亡率升高有显著相关性。在二元logistic回归分析中,肺栓塞严重程度指数(PESI)评分每增加一个单位,死亡率增加2.2倍(95% CI:1.03-5.09),大量PTE增加1.6倍(95% CI:0.14-17.86),抗凝时间(每天)增加0.98倍(95% CI:0.98-0.99), Hb水平(每单位Hb减少)增加0.67倍(95% CI:0.45-1.02)。低、高PESI患者住院天数及简化PE严重程度指数(sPESI)评分差异无统计学意义。结论:肺栓塞患者的全因死亡率随着年龄、心脏病和COPD合并症的增加而增加。在PTE急性期使用的PESI和sPESI评分在预测PE患者的全因死亡率方面是高度可靠的。大量PE的诊断和NT-proBNP水平升高(右室功能障碍的标志)是增加死亡率的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictors of Mortality in Pulmonary Embolism: A Real-Life Study
Objective: The primary aim of this study was to investigate the mortality and associated factors in patients with pulmonary embolism. Methods: A retrospective analysis was performed on adult patients with pulmonary embolism who applied to X University Hospital between January 1, 2017, and January 1, 2023. All-cause mortality and related factors in pulmonary embolism patients were determined. Results: This study included 152 patients with a median age of 59 years and 81 (53.3%) women. The all-cause mortality rate was 25.7%, and pulmonary embolism-related deaths were 1.3%. Age (p<0.001), chronic obstructive pulmonary disease (COPD) (p=0.013), heart failure (p=0.018), atrial fibrillation (p=0.015), massive pulmonary embolism (p=0.029), hemoglobin level (p<0.001) and NT-Pro BNP level (p<0.001) were significantly associated with increased all-cause mortality. In binary logistic regression analysis, for each unit of increasing pulmonary embolism severity index (PESI) score, mortality increased 2.2-fold (95% CI:1.03-5.09), massive PTE 1.6-fold (95% CI:0.14-17.86), anticoagulant duration (daily) 0.98-fold (95% CI:0.98-0.99) and Hb level (per unit Hb reduction) 0.67-fold (95% CI:0.45-1.02) mortality was increasing. There was no statistical difference between the number of hospitalization days for patients with low and high PESI and simplified PE severity index (sPESI) scores. Conclusions: All-cause mortality in patients with pulmonary embolism increased with age, cardiac diseases, and COPD comorbidities. The PESI and sPESI scores used in the acute phase of PTE were found to be highly reliable in predicting all-cause mortality in PE patients. The diagnosis of massive PE and elevated NT-proBNP levels, a marker of right ventricular dysfunction, were factors that increased mortality.
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来源期刊
European Journal of Therapeutics
European Journal of Therapeutics MEDICINE, GENERAL & INTERNAL-
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