生产用水的细菌学分析

M. Khan
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引用次数: 0

摘要

目的:测定生产用水(化妆品、药品等)的细菌学质量。材料与方法:对20份来自巴基斯坦白沙瓦知名制药公司的药用水样进行了实验研究。采用传统的培养和生化方法从获得的水样中枚举总体微生物负荷和特定病原体。结果:所有样品的好氧活菌总负荷均低于可接受限度(200 CFU/mL),检出假单胞菌(n=03)和大肠杆菌(n=01)。在任何样本中均未发现金黄色葡萄球菌和沙门氏菌的证据。结论本研究提供了制药用水的全面细菌学概况,并表明特定细菌的存在可能对最终药品产生重大的毒性和危害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacteriological profile of pharmaceutical water used for production purpose
Objectives: To determine the bacteriological quality of pharmaceutical water used for production purposes (cosmetics, medicine, etc.). Materials and methods: An experimental study was conducted of 20 pharmaceutical water samples, collected from reputed pharmaceutical companies located in Peshawar, Pakistan. To enumerate the overall microbial load and particular pathogens from the obtained water samples traditional culture and biochemical approaches were used. Results: A total aerobic viable bacterial load of all samples were found below the acceptable limit (200 CFU/mL) while, Pseudomonas species were found (n=03), and Escherichia coli was found (n=01). No evidence of Staphylococcus aureus and Salmonella species were found in any of the samples. Conclusion The current study provides a comprehensive bacteriological profile of pharmaceutical water and demonstrates that the presence of particular bacteria might cause significant toxicity and hazard in final pharmaceutical products.
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