用CaBr2沉淀法轻松去除反应混合物中的氧化三苯基膦

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2022-06-09 DOI:10.1021/acs.oprd.2c00104

Antonio Rodríguez Hergueta*,

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引用次数: 1

摘要

开发了一种可靠且可扩展的纯化方法，通过与CaBr2在乙醚溶剂或甲苯中络合去除氧化三苯基膦。所得的不溶性沉淀络合物通过过滤很容易从粗反应混合物中高收率地去除，而不需要柱层析纯化。研究了该方法与不同有机溶剂、盐、助滤剂、包装材料和几种含有最常见有机官能团的分子的相容性，以探索该方法的范围和局限性。此外，还探讨了与其他卤化物盐络合沉淀TPPO的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Easy Removal of Triphenylphosphine Oxide from Reaction Mixtures by Precipitation with CaBr2

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Easy Removal of Triphenylphosphine Oxide from Reaction Mixtures by Precipitation with CaBr2

A reliable and scalable purification procedure for the easy removal of triphenylphosphine oxide by complexation with CaBr₂ in ethereal solvents or toluene was developed. The resulting insoluble precipitated complex was easily eliminated from crude reaction mixtures in high yields by filtration without the need of purification by column chromatography. The compatibility of this procedure with different organic solvents, salts, filtration aids, packing materials, and several molecules containing most common organic functional groups was examined to explore the scope and limitations of this method. Additionally, precipitation of TPPO by complexation with other halide salts was also explored.

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.