固体脂质纳米颗粒作为辛酸载体的药理学参数评价

IF 1.5 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Micro & Nano Letters Pub Date : 2023-05-05 DOI:10.3390/micro3020034

Stefano Russo, Giuliana Greco, M. Sarpietro

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引用次数: 0

摘要

Sinapic acid, 3,5-二甲氧基-4-羟基肉桂酸，属于羟基肉桂酸类，具有抗氧化、抗炎、抗癌、保肝、保心、保肾、保神经、抗糖尿病、抗焦虑和抗菌活性。本研究的目的是将辛酸掺入固体脂质纳米颗粒中，以提高其生物利用度。采用高温高速均质法制备了sln。研究了sinapic酸包膜sln的药理学性能和热致性，以及它们与生物膜模型的相互作用。sln具有良好的理化性能、包封效率和良好的释放特性;此外，它们促进了辛酸与由多层囊泡组成的生物膜模型的相互作用。综上所述，该配方可用于进一步的研究，以评估其提高辛酸活性的适用性。

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Assessment of Pharmaco-Technological Parameters of Solid Lipid Nanoparticles as Carriers for Sinapic Acid

Sinapic acid, 3,5-dimethoxyl-4-hydroxycinnamic acid, belonging to the class of hydroxycinnamic acids, shows antioxidant, anti-inflammatory, anticancer, hepatoprotective, cardioprotective, renoprotective, neuroprotective, antidiabetic, anxiolytic, and antibacterial activity. The aim of this work was to incorporate sinapic acid into solid lipid nanoparticles in order to improve its bioavailability. SLNs were prepared using the hot high-speed homogenization method. The pharmaco-technological properties and thermotropic profile of SLNs encapsulated with sinapic acid, as well as their interaction with biomembrane models, were evaluated. SLNs showed promising physicochemical properties and encapsulation efficiency, as well as a desirable release profile; moreover, they facilitated the interaction of sinapic acid with a biomembrane model made of multilamellar vesicles. In conclusion, this formulation can be used in further studies to assess its suitability to improve sinapic acid activity.

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来源期刊

Micro & Nano Letters 工程技术-材料科学：综合

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.8 months

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