类器官生物打印技术及其在生物医学中的应用综述

IF 6.8 3区医学 Q1 ENGINEERING, BIOMEDICAL

International Journal of Bioprinting Pub Date : 2023-06-30 DOI:10.36922/ijb.0112

Chen He, Jiasheng Yan, Yusheng Fu, Jiuchuan Guo, Yuxing Shi, Jinhong Guo

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引用次数: 0

摘要

类器官是体外培养的三维细胞结构。它们是自组织的，可以在结构和功能上模仿真实的器官。生物打印技术突破了类器官制造的一些局限性，使其在药物筛选、再生医学等领域得到了更广泛的应用。本文首先介绍了用于干细胞和类器官生物打印的生物墨水和生物打印方法，然后总结了几种用于类器官生物打印的血管化策略及其在生物医学中的应用。未来，微流控技术和四维生物打印技术的发展可能有助于形成更好的生物打印类器官。

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Organoid bioprinting strategy and application in biomedicine: A review

Organoids are three-dimensional cell structures cultured in vitro. They are self-organizing and can mimic real organs in structure and function. Bioprinting technology breaks through some limitations of organoid manufacturing, making it more widely used in drug screening, regenerative medicine, and other fields. In this review, we first introduce bioinks and bioprinting methods for stem cell and organoid bioprinting, then summarize several vascularization strategies for bioprinting organoids, and present applications in biomedicine. In the future, the development of microfluidic technology and four-dimensional bioprinting technology may be conducive to forming better bioprinted organoids.

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来源期刊

International Journal of Bioprinting Multiple-

CiteScore

6.90

自引率

4.80%

发文量

期刊介绍： The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.