外周血NUMB低表达与急性心肌梗死的关系

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research and Practice Pub Date : 2022-04-26 DOI:10.1155/2022/7981637

Heyu Meng, Lihong Li, Jianjun Ruan, Yanqiu Chen, Zhaohan Yan, Jinsha Liu, Xiangdong Li, Cuiying Mao, Ping Yang

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引用次数: 2

摘要

目的了解急性心肌梗死(AMI)患者的NUMB基因表达模式，并评价其作为AMI诊断标志物的作用。方法选取124例急性心肌梗死患者和115例稳定型冠状动脉疾病(SCAD)患者的外周血。采用实时定量聚合酶链反应法检测小鼠外周血NUMB基因mRNA表达水平。结果AMI组NUMB基因表达量为0.906 (0.181 ~ 0.954)，SCAD组NUMB基因表达量为1.024(0.207 ~ 1.127)。AMI组的NUMB mRNA表达量比SCAD组低0.885倍(P < 0.05)。结论多因素logistic回归评价发现，低NUMB表达与冠状动脉疾病风险增加相关。然而，年龄和空腹血糖水平与NUMB表达降低无关。

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Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction

Objective Our study's goal was to find out acute myocardial infarction (AMI) patients' NUMB gene expression patterns and to evaluate its role as a diagnostic marker for AMI detection. Methods Peripheral blood was drawn from 124 individuals who had an AMI and 115 patients who had stable coronary artery disease (SCAD). The real-time quantitative polymerase chain reaction was used to measure the mRNA expression level of the NUMB gene in peripheral blood. Results The AMI group's NUMB gene expression was 0.906 (0.181–0.954), whereas the SCAD group's expression was 1.024 (0.207–1.127). However, the AMI group had 0.885 times lower NUMB mRNA expression than the SCAD group (P < 0.05). Conclusion Multivariate logistic regression evaluation found that lower NUMB expression was correlated with an increased risk of coronary artery disease. However, age and fasting plasma glucose levels were not associated with decreased NUMB expression.

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来源期刊

Cardiology Research and Practice Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Cardiology Research and Practice is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies that focus on the diagnosis and treatment of cardiovascular disease. The journal welcomes submissions related to systemic hypertension, arrhythmia, congestive heart failure, valvular heart disease, vascular disease, congenital heart disease, and cardiomyopathy.