{"title":"红树林土壤次生代谢物来源真菌Xylariaceae sp. SCSIO41212","authors":"Jingxia HUANG , Ying CHEN , Yanchun HE , Bin YANG","doi":"10.1016/S2707-3688(23)00043-2","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To obtain structurally novel and bioactive secondary metabolites from the marine fungus <em>Xylariaceae</em> sp. SCSIO41212.</p></div><div><h3>Methods</h3><p>Compounds were purified by comprehensive chromatography methods of silica gel column, Sephadex LH-20, Ostade-cylsilane (ODS) and semi-preparative HPLC, and their structures were elucidated by means of physical and chemical properties, magnefic resonance imaging, spectroscopic analysis, and comparison with the reported literatures.</p></div><div><h3>Results</h3><p>Chemical investigation of the fungus <em>Xylariaceae</em> sp. SCSIO41212 has led to the isolation of two new compounds, xylaolide B <strong>(1)</strong> and xylaolide C <strong>(2),</strong> together with nine known compounds <strong>(3–11</strong>). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. Compounds <strong>1–6</strong> were evaluated for their antiviral, and cytotoxic activities, respectively. Compound <strong>1</strong> showed weak cytotoxicities against K562, MCF-7 and SGC7901 respectively.</p></div><div><h3>Conclusion</h3><p>This study enriches the diversity of secondary metabolites of marine-derived fungi and provides an important reference for novel promising drug leads research.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"3 3","pages":"Pages 230-235"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368823000432/pdfft?md5=91ca9145caef8cc74bcfebab4ae63360&pid=1-s2.0-S2707368823000432-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Secondary metabolites from the mangrove soil derived fungus Xylariaceae sp. SCSIO41212\",\"authors\":\"Jingxia HUANG , Ying CHEN , Yanchun HE , Bin YANG\",\"doi\":\"10.1016/S2707-3688(23)00043-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To obtain structurally novel and bioactive secondary metabolites from the marine fungus <em>Xylariaceae</em> sp. SCSIO41212.</p></div><div><h3>Methods</h3><p>Compounds were purified by comprehensive chromatography methods of silica gel column, Sephadex LH-20, Ostade-cylsilane (ODS) and semi-preparative HPLC, and their structures were elucidated by means of physical and chemical properties, magnefic resonance imaging, spectroscopic analysis, and comparison with the reported literatures.</p></div><div><h3>Results</h3><p>Chemical investigation of the fungus <em>Xylariaceae</em> sp. SCSIO41212 has led to the isolation of two new compounds, xylaolide B <strong>(1)</strong> and xylaolide C <strong>(2),</strong> together with nine known compounds <strong>(3–11</strong>). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. Compounds <strong>1–6</strong> were evaluated for their antiviral, and cytotoxic activities, respectively. Compound <strong>1</strong> showed weak cytotoxicities against K562, MCF-7 and SGC7901 respectively.</p></div><div><h3>Conclusion</h3><p>This study enriches the diversity of secondary metabolites of marine-derived fungi and provides an important reference for novel promising drug leads research.</p></div>\",\"PeriodicalId\":100787,\"journal\":{\"name\":\"Journal of Holistic Integrative Pharmacy\",\"volume\":\"3 3\",\"pages\":\"Pages 230-235\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000432/pdfft?md5=91ca9145caef8cc74bcfebab4ae63360&pid=1-s2.0-S2707368823000432-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Holistic Integrative Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000432\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Holistic Integrative Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2707368823000432","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Secondary metabolites from the mangrove soil derived fungus Xylariaceae sp. SCSIO41212
Objective
To obtain structurally novel and bioactive secondary metabolites from the marine fungus Xylariaceae sp. SCSIO41212.
Methods
Compounds were purified by comprehensive chromatography methods of silica gel column, Sephadex LH-20, Ostade-cylsilane (ODS) and semi-preparative HPLC, and their structures were elucidated by means of physical and chemical properties, magnefic resonance imaging, spectroscopic analysis, and comparison with the reported literatures.
Results
Chemical investigation of the fungus Xylariaceae sp. SCSIO41212 has led to the isolation of two new compounds, xylaolide B (1) and xylaolide C (2), together with nine known compounds (3–11). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. Compounds 1–6 were evaluated for their antiviral, and cytotoxic activities, respectively. Compound 1 showed weak cytotoxicities against K562, MCF-7 and SGC7901 respectively.
Conclusion
This study enriches the diversity of secondary metabolites of marine-derived fungi and provides an important reference for novel promising drug leads research.
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