评估慢性阻塞性肺疾病患者骨质疏松和骨质减少及其与疾病严重程度的相关危险因素:印度病例对照研究

M. Daga, D. Bharali, Gupta Bk, G. Mawari, H. Hira, T. Sekhri
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引用次数: 8

摘要

慢性阻塞性肺疾病(COPD)是发病率和死亡率的主要原因,造成经济和社会负担。骨质疏松被认为是COPD的主要全身性表现之一。目的和目的:确定COPD患者骨质疏松的患病率及其疾病严重程度,并评估COPD患者骨密度降低的各种危险因素。方法:选取30例COPD患者和15例健康对照,进行肺功能检查和DEXA扫描。研究和分析COPD合并骨质疏松的各种危险因素以及骨质疏松与COPD严重程度的关系。参数资料采用t检验进行统计分析。P值<0.05为差异有统计学意义。结果:COPD患者骨质疏松的发生率(60%)明显高于健康成人(20%)(p=0.017)。51 ~ 60岁COPD患者骨质疏松率明显高于其他年龄段COPD患者。肥胖、超重和吸烟习惯以及病情加重可能是COPD患者的危险因素。COPD患者平均加重次数为2.13次。COPD黄金2期患者骨质疏松较少,而大多数3期和4期患者骨质疏松。T评分、骨密度与对照组比较差异有统计学意义(p=0.007)。健康对照组的骨密度高于COPD患者(p=0.012)。41-50岁年龄组的骨密度高于51-60岁年龄组。(p = 0.021)。结论:骨质疏松和骨质减少的风险随COPD严重程度的增加而增加。有多种危险因素被发现与COPD患者骨质疏松和骨质减少有关。因此,本研究值得进一步的COPD研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Osteoporosis and Osteopenia and its Co-Relation with Disease Severity in Patients of Chronic Obstructive Pulmonary Disease with Respect to Associated Risk Factors: A Case Control Study in India
Introduction: Chronic obstructive pulmonary disease (COPD) is the major cause of morbidity and mortality which results in an economic and social burden. Osteoporosis is considered as one of the major systemic manifestations of COPD. Aim and Objective: It is to determine the prevalence of osteoporosis in COPD patients and its disease severity and also to evaluate various risk factors involved in reduced bone mineral density in patients with COPD. Methods: A total of 30 COPD patients and 15 healthy controls were enrolled and all individuals were subjected to pulmonary function test and DEXA scan. Various risk factors for COPD associated with osteoporosis and association of osteoporosis with severity of COPD were studied and analyzed. Statistical analysis was done for parametric data using t-test. p value <0.05 was considered as significant.Results: The incidence of osteoporosis was found to be significantly higher in COPD patients (60%) compared to healthy adults (20%) (p=0.017). Osteoporosis within the COPD patients of age group of 51-60 was found to be significantly higher compared to other age group in COPD. Obesity, overweight and smoking habit as well as exacerbations may be the risk factors in COPD patients. The average number of exacerbation in COPD patients was 2.13. COPD Patients in Gold Stage 2 had less osteoporosis while majority of patients in stage 3 and stage 4 had osteoporosis. T score and BMD differed significantly between the cases and control (p=0.007). BMD was higher in healthy controls compared to COPD patients (p=0.012). BMD has higher in age group of 41-50 compared to age group 51-60. (p=0.021).Conclusion: The risk of osteoporosis and osteopenia increases with the increase of COPD severity. There are multiple risk factors which are found to be associated with osteoporosis and osteopenia in COPD. Thus the present study warrants further COPD study.
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