芯片上的白血病-电阻抗谱作为在线读数来研究药物-癌症相互作用

2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) Pub Date : 2019-06-23 DOI:10.1109/TRANSDUCERS.2019.8808781

Furkan Gökçe, Paolo S. Ravaynia, A. Kaestli, M. Modena, A. Hierlemann, K. Renggli

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引用次数: 0

摘要

基于微生理系统领域的最新进展，我们建立了一个白血病芯片的概念，通过在微流控系统中连续循环白血病细胞来模拟体外血癌。该平台由集成电阻抗光谱(EIS)单元补充，能够实时监测流动的癌细胞。在白血病细胞死亡后，膜的电导率和介电性质等电参数会发生改变。因此，通过EIS可以在线和无标签地研究药物-癌症相互作用。在这项研究中，我们提出了概念验证实验结果，显示了EIS在实时药物疗效研究中的潜力。

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Leukemia On Chip – Electrical Impedance Spectroscopy As An Online Readout To Investigate Drug-Cancer Interaction

Based on recent advances in the field of microphysiological systems, we established a Leukemiaon-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) unit that enables to monitor the flowing cancer cells in real-time. The electric parameters, such as membrane conductivity and dielectric properties, alter upon the death of leukemia cells. Thus, drug-cancer interactions can be studied online and label-free by means of EIS. In this study, we present proof-of-concept experimental results that show the potential of EIS for real-time drug efficacy research.

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来源期刊

2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

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